4n6p: Difference between revisions

Line 1:

~~{{STRUCTURE_4n6p| PDB=4n6p | SCENE= }}~~

==Crystal Structure of C-lobe of Bovine lactoferrin complexed with meclofenamic acid at 1.4 A resolution==

===Crystal Structure of C-lobe of Bovine lactoferrin complexed with meclofenamic acid at 1.4 A resolution===

== Structural highlights ==

<table><tr><td colspan='2'>[[4n6p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N6P FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=JMS:2-[(2,6-DICHLORO-3-METHYL-PHENYL)AMINO]BENZOIC+ACID'>JMS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n6p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n6p RCSB], [http://www.ebi.ac.uk/pdbsum/4n6p PDBsum]</span></td></tr>

</table>

==~~Function~~==

==See Also==

[[http://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>

*[[Lactoferrin|Lactoferrin]]

__TOC__

~~==About this Structure==~~

</StructureSection>

~~[[4n6p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N6P OCA~~].

~~==Reference==~~

~~<references group="xtra"/>~~<~~references~~/>

[[Category: Bos taurus]]

[[Category: Dube, D.]]

[[Category: Dube, D]]

[[Category: Gautam, L.]]

[[Category: Gautam, L]]

[[Category: Kaur, P.]]

[[Category: Kaur, P]]

[[Category: Sharma, S.]]

[[Category: Sharma, S]]

[[Category: Singh, T P.]]

[[Category: Singh, T P]]

[[Category: Sinha, M.]]

[[Category: Sinha, M]]

[[Category: C-lobe]]

[[Category: Hydrolase]]

[[Category: Meclofenamic acid]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_4n6p|  PDB=4n6p  |  SCENE=  }}
+==Crystal Structure of C-lobe of Bovine lactoferrin complexed with meclofenamic acid at 1.4 A resolution==
-===Crystal Structure of C-lobe of Bovine lactoferrin complexed with meclofenamic acid at 1.4 A resolution===
+<StructureSection load='4n6p' size='340' side='right' caption='[[4n6p]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4n6p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N6P FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=JMS:2-[(2,6-DICHLORO-3-METHYL-PHENYL)AMINO]BENZOIC+ACID'>JMS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n6p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n6p RCSB], [http://www.ebi.ac.uk/pdbsum/4n6p PDBsum]</span></td></tr>
+</table>
-==Function==
+==See Also==
-[[http://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>   Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>   Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>   The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>
+*[[Lactoferrin|Lactoferrin]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[4n6p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N6P OCA].
-==Reference==
-<references group="xtra"/><references/>
 [[Category: Bos taurus]]
-[[Category: Dube, D.]]
+[[Category: Dube, D]]
-[[Category: Gautam, L.]]
+[[Category: Gautam, L]]
-[[Category: Kaur, P.]]
+[[Category: Kaur, P]]
-[[Category: Sharma, S.]]
+[[Category: Sharma, S]]
-[[Category: Singh, T P.]]
+[[Category: Singh, T P]]
-[[Category: Sinha, M.]]
+[[Category: Sinha, M]]
 [[Category: C-lobe]]
 [[Category: Hydrolase]]
 [[Category: Meclofenamic acid]]