4lv5: Difference between revisions

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{{STRUCTURE_4lv5|  PDB=4lv5  |  SCENE=  }}
==Murine IRGa6 bound to Toxoplasma ROP5B, a pseudokinase GDI==
===Murine IRGa6 bound to Toxoplasma ROP5B, a pseudokinase GDI===
<StructureSection load='4lv5' size='340' side='right' caption='[[4lv5]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[4lv5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LV5 FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/IIGP1_MOUSE IIGP1_MOUSE]] GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.<ref>PMID:11907101</ref> <ref>PMID:16304607</ref> <ref>PMID:19242543</ref> <ref>PMID:12732635</ref>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lv8|4lv8]]</td></tr>
==About this Structure==
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ROP5, ROP5B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 Toxoplasma gondii]), Iigp1, Irga6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
[[4lv5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LV5 OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lv5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lv5 RCSB], [http://www.ebi.ac.uk/pdbsum/4lv5 PDBsum]</span></td></tr>
 
</table>
==Reference==
__TOC__
<references group="xtra"/><references/>
</StructureSection>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Toxoplasma gondii]]
[[Category: Toxoplasma gondii]]
[[Category: Boothroyd, J C.]]
[[Category: Boothroyd, J C]]
[[Category: Reese, M L.]]
[[Category: Reese, M L]]
[[Category: Guanine dissociation inhibitor]]
[[Category: Guanine dissociation inhibitor]]
[[Category: Immune related gtpase]]
[[Category: Immune related gtpase]]
[[Category: Parasite effector]]
[[Category: Parasite effector]]
[[Category: Transferase-hydrolase complex]]
[[Category: Transferase-hydrolase complex]]
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