4l3n: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus== | |||
<StructureSection load='4l3n' size='340' side='right' caption='[[4l3n]], [[Resolution|resolution]] 2.13Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4l3n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_betacoronavirus_2c_jordan-n3/2012 Human betacoronavirus 2c jordan-n3/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L3N FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1306931 Human betacoronavirus 2c Jordan-N3/2012])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l3n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l3n RCSB], [http://www.ebi.ac.uk/pdbsum/4l3n PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) has infected at least 77 people with a fatality rate of more than 50%. Alarmingly, the virus demonstrates a capability of human-to-human transmission, raising the possibility of global spread and endangering world health and economy. Here we have identified the receptor-binding domain (RBD) from the MERS-CoV spike protein and determined its crystal structure. This study also presents the structural comparison of MERS-CoV RBD with other coronavirus RBDs, successfully positioning MERS-CoV on the landscape of coronavirus evolution and providing insights into receptor binding by MERS-CoV. Furthermore, we found that MERS-CoV RBD functions as an effective entry inhibitor of MERS-CoV. The identified MERS-CoV RBD may also serve as a potential candidate for MERS-CoV subunit vaccines. Overall, this study enhances our understanding of the evolution of coronavirus RBDs, provides insights into receptor recognition by MERS-CoV, and may help control the transmission of MERS-CoV in humans. | |||
Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus.,Chen Y, Rajashankar KR, Yang Y, Agnihothram SS, Liu C, Lin YL, Baric RS, Li F J Virol. 2013 Jul 31. PMID:23903833<ref>PMID:23903833</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human betacoronavirus 2c jordan-n3/2012]] | [[Category: Human betacoronavirus 2c jordan-n3/2012]] | ||
[[Category: Agnihothram, S S | [[Category: Agnihothram, S S]] | ||
[[Category: Baric, R S | [[Category: Baric, R S]] | ||
[[Category: Chen, Y | [[Category: Chen, Y]] | ||
[[Category: Li, F | [[Category: Li, F]] | ||
[[Category: Lin, Y L | [[Category: Lin, Y L]] | ||
[[Category: Liu, C | [[Category: Liu, C]] | ||
[[Category: Rajashankar, K R | [[Category: Rajashankar, K R]] | ||
[[Category: Yang, Y | [[Category: Yang, Y]] | ||
[[Category: Beta-sheet fold]] | [[Category: Beta-sheet fold]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
