4kc2: Difference between revisions

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{{STRUCTURE_4kc2|  PDB=4kc2  |  SCENE=  }}
==Structure of the blood group glycosyltransferase AAglyB in complex with a pyridine inhibitor as a neutral pyrophosphate surrogate==
===Structure of the blood group glycosyltransferase AAglyB in complex with a pyridine inhibitor as a neutral pyrophosphate surrogate===
<StructureSection load='4kc2' size='340' side='right' caption='[[4kc2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[4kc2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KC2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KC2 FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BHE:OCTYL+2-O-(6-DEOXY-ALPHA-L-GALACTOPYRANOSYL)-BETA-D-GALACTOPYRANOSIDE'>BHE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=WS2:6-(1-BETA-D-GALACTOPYRANOSYLOXYMETHYL)-N-(5-DEOXYLURIDINE-5-YL)PICOLINAMIDE'>WS2</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kc1|4kc1]]</td></tr>
==About this Structure==
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
[[4kc2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KC2 OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kc2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kc2 RCSB], [http://www.ebi.ac.uk/pdbsum/4kc2 PDBsum]</span></td></tr>
</table>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Cuesta-Seijo, J A.]]
[[Category: Cuesta-Seijo, J A]]
[[Category: Lafont, D.]]
[[Category: Lafont, D]]
[[Category: Palcic, M M.]]
[[Category: Palcic, M M]]
[[Category: Vidal, S.]]
[[Category: Vidal, S]]
[[Category: Wang, S.]]
[[Category: Wang, S]]
[[Category: Blood group protein]]
[[Category: Blood group protein]]
[[Category: Fuc-gal]]
[[Category: Fuc-gal]]

Revision as of 15:22, 21 December 2014

Structure of the blood group glycosyltransferase AAglyB in complex with a pyridine inhibitor as a neutral pyrophosphate surrogate

4kc2, resolution 1.70Å

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