4l7j: Difference between revisions

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~~{{STRUCTURE_4l7j| PDB=4l7j | SCENE= }}~~

==Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1)==

===Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1)===

== Structural highlights ==

<table><tr><td colspan='2'>[[4l7j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7J OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L7J FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=1W2:2-[(3AS,7AR)-2-AMINO-3A-(2,4-DIFLUOROPHENYL)-3A,6,7,7A-TETRAHYDRO[1,3]OXAZOLO[4,5-C]PYRIDIN-5(4H)-YL]PYRIDINE-3-CARBONITRILE'>1W2</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4l7g|4l7g]], [[4l7h|4l7h]], [[4lc7|4lc7]]</td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l7j RCSB], [http://www.ebi.ac.uk/pdbsum/4l7j PDBsum]</td></tr>

</table>

==~~Function~~==

==See Also==

[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase~~.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>~~

*[[Beta secretase|Beta secretase]]

__TOC__

~~==About this Structure==~~

</StructureSection>

~~[[4l7j~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7J OCA].

~~==Reference==~~

~~<references group="xtra"/>~~<~~references~~/>

[[Category: Homo sapiens]]

[[Category: Memapsin 2]]

[[Category: Do, M K.Geck.]]

[[Category: Do, M K.Geck]]

[[Category: Dutcher, D.]]

[[Category: Dutcher, D]]

[[Category: Huestis, M P.]]

[[Category: Huestis, M P]]

[[Category: Hunt, K W.]]

[[Category: Hunt, K W]]

[[Category: Liu, W.]]

[[Category: Liu, W]]

[[Category: Purkey, H E.]]

[[Category: Purkey, H E]]

[[Category: Siu, M.]]

[[Category: Siu, M]]

[[Category: Smith, D.]]

[[Category: Smith, D]]

[[Category: Vigers, G.]]

[[Category: Vigers, G]]

[[Category: Volgraf, M.]]

[[Category: Volgraf, M]]

[[Category: Wang, W.]]

[[Category: Wang, W]]

[[Category: Wu, P.]]

[[Category: Wu, P]]

[[Category: Yu, C.]]

[[Category: Yu, C]]

[[Category: Aspartic protease]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_4l7j|  PDB=4l7j  |  SCENE=  }}
+==Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1)==
-===Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1)===
+<StructureSection load='4l7j' size='340' side='right' caption='[[4l7j]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4l7j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L7J FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1W2:2-[(3AS,7AR)-2-AMINO-3A-(2,4-DIFLUOROPHENYL)-3A,6,7,7A-TETRAHYDRO[1,3]OXAZOLO[4,5-C]PYRIDIN-5(4H)-YL]PYRIDINE-3-CARBONITRILE'>1W2</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l7g|4l7g]], [[4l7h|4l7h]], [[4lc7|4lc7]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l7j RCSB], [http://www.ebi.ac.uk/pdbsum/4l7j PDBsum]</span></td></tr>
+</table>
-==Function==
+==See Also==
-[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
+*[[Beta secretase|Beta secretase]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[4l7j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7J OCA].
-==Reference==
-<references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Memapsin 2]]
-[[Category: Do, M K.Geck.]]
+[[Category: Do, M K.Geck]]
-[[Category: Dutcher, D.]]
+[[Category: Dutcher, D]]
-[[Category: Huestis, M P.]]
+[[Category: Huestis, M P]]
-[[Category: Hunt, K W.]]
+[[Category: Hunt, K W]]
-[[Category: Liu, W.]]
+[[Category: Liu, W]]
-[[Category: Purkey, H E.]]
+[[Category: Purkey, H E]]
-[[Category: Siu, M.]]
+[[Category: Siu, M]]
-[[Category: Smith, D.]]
+[[Category: Smith, D]]
-[[Category: Vigers, G.]]
+[[Category: Vigers, G]]
-[[Category: Volgraf, M.]]
+[[Category: Volgraf, M]]
-[[Category: Wang, W.]]
+[[Category: Wang, W]]
-[[Category: Wu, P.]]
+[[Category: Wu, P]]
-[[Category: Yu, C.]]
+[[Category: Yu, C]]
 [[Category: Aspartic protease]]
 [[Category: Hydrolase-hydrolase inhibitor complex]]