1sj0: Difference between revisions

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[[Image:1sj0.gif|left|200px]]~~<br /><applet load~~="1sj0~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1sj0.gif|left|200px]]

~~caption="~~1sj0, resolution 1.90Å" />

'''Human Estrogen Receptor Alpha Ligand-binding Domain in Complex with the Antagonist Ligand 4-D'''~~<br />~~

{{Structure

|PDB= 1sj0 |SIZE=350|CAPTION= <scene name='initialview01'>1sj0</scene>, resolution 1.90Å

|SITE=

|LIGAND= <scene name='pdbligand=E4D:(2S,3R)-2-(4-(2-(PIPERIDIN-1-YL)ETHOXY)PHENYL)-2,3-DIHYDRO-3-(4-HYDROXYPHENYL)BENZO[B][1,4]OXATHIIN-6-OL'>E4D</scene>

|ACTIVITY=

|GENE= ESR1, NR3A1, ESR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])

}}

'''Human Estrogen Receptor Alpha Ligand-binding Domain in Complex with the Antagonist Ligand 4-D'''

==Overview==

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==About this Structure==

1SJ0 is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~] with <scene name='pdbligand=E4D:'>E4D</scene> as [http://en.wikipedia.org/wiki/ligand ligand~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJ0 OCA].

1SJ0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJ0 OCA].

==Reference==

Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators., Kim S, Wu JY, Birzin ET, Frisch K, Chan W, Pai LY, Yang YT, Mosley RT, Fitzgerald PM, Sharma N, Dahllund J, Thorsell AG, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML, J Med Chem. 2004 Apr 22;47(9):2171-5. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~15084115 15084115]

Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators., Kim S, Wu JY, Birzin ET, Frisch K, Chan W, Pai LY, Yang YT, Mosley RT, Fitzgerald PM, Sharma N, Dahllund J, Thorsell AG, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML, J Med Chem. 2004 Apr 22;47(9):2171-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15084115 15084115]

[[Category: Homo sapiens]]

[[Category: Single protein]]

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[[Category: transcription factor]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:05:32 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1sj0.gif|left|200px]]<br /><applet load="1sj0" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1sj0.gif|left|200px]]
-caption="1sj0, resolution 1.90&Aring;" />
-'''Human Estrogen Receptor Alpha Ligand-binding Domain in Complex with the Antagonist Ligand 4-D'''<br />
+ {{Structure
+|PDB= 1sj0 |SIZE=350|CAPTION= <scene name='initialview01'>1sj0</scene>, resolution 1.90&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=E4D:(2S,3R)-2-(4-(2-(PIPERIDIN-1-YL)ETHOXY)PHENYL)-2,3-DIHYDRO-3-(4-HYDROXYPHENYL)BENZO[B][1,4]OXATHIIN-6-OL'>E4D</scene>
+|ACTIVITY=
+|GENE= ESR1, NR3A1, ESR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''Human Estrogen Receptor Alpha Ligand-binding Domain in Complex with the Antagonist Ligand 4-D'''
 ==Overview==
@@ Line 10: / Line 19: @@
 ==About this Structure==
-SJ0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=E4D:'>E4D</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJ0 OCA].
+SJ0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJ0 OCA].
 ==Reference==
-Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators., Kim S, Wu JY, Birzin ET, Frisch K, Chan W, Pai LY, Yang YT, Mosley RT, Fitzgerald PM, Sharma N, Dahllund J, Thorsell AG, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML, J Med Chem. 2004 Apr 22;47(9):2171-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15084115 15084115]
+Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators., Kim S, Wu JY, Birzin ET, Frisch K, Chan W, Pai LY, Yang YT, Mosley RT, Fitzgerald PM, Sharma N, Dahllund J, Thorsell AG, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML, J Med Chem. 2004 Apr 22;47(9):2171-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15084115 15084115]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 35: / Line 44: @@
 [[Category: transcription factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:02:02 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:05:32 2008''