1skm: Difference between revisions

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[[Image:1skm.gif|left|200px]]<br /><applet load="1skm" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1skm.gif|left|200px]]
caption="1skm, resolution 2.2&Aring;" />
 
'''HhaI methyltransferase in complex with DNA containing an abasic south carbocyclic sugar at its target site'''<br />
{{Structure
|PDB= 1skm |SIZE=350|CAPTION= <scene name='initialview01'>1skm</scene>, resolution 2.2&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37]
|GENE= HHAIM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=726 Haemophilus haemolyticus])
}}
 
'''HhaI methyltransferase in complex with DNA containing an abasic south carbocyclic sugar at its target site'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1SKM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_haemolyticus Haemophilus haemolyticus] with <scene name='pdbligand=SAH:'>SAH</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKM OCA].  
1SKM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_haemolyticus Haemophilus haemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKM OCA].  


==Reference==
==Reference==
Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase., Horton JR, Ratner G, Banavali NK, Huang N, Choi Y, Maier MA, Marquez VE, MacKerell AD Jr, Cheng X, Nucleic Acids Res. 2004 Jul 23;32(13):3877-86. Print 2004. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15273274 15273274]
Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase., Horton JR, Ratner G, Banavali NK, Huang N, Choi Y, Maier MA, Marquez VE, MacKerell AD Jr, Cheng X, Nucleic Acids Res. 2004 Jul 23;32(13):3877-86. Print 2004. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15273274 15273274]
[[Category: DNA (cytosine-5-)-methyltransferase]]
[[Category: DNA (cytosine-5-)-methyltransferase]]
[[Category: Haemophilus haemolyticus]]
[[Category: Haemophilus haemolyticus]]
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[[Category: protein-dna complex containing constrained abasic unnatural base]]
[[Category: protein-dna complex containing constrained abasic unnatural base]]


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