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{{STRUCTURE_3odw|  PDB=3odw  |  SCENE=  }}
==Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF==
===Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF===
<StructureSection load='3odw' size='340' side='right' caption='[[3odw]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[3odw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ODW FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN]] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3odo|3odo]], [[1txd|1txd]], [[1xcg|1xcg]], [[3kz1|3kz1]], [[1x86|1x86]], [[3odx|3odx]]</td></tr>
 
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARHGEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3odw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3odw RCSB], [http://www.ebi.ac.uk/pdbsum/3odw PDBsum]</span></td></tr>
[[3odw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODW OCA].  
</table>
 
__TOC__
==Reference==
</StructureSection>
<references group="xtra"/><references/>
[[Category: Human]]
[[Category: Human]]
[[Category: Chen, Z.]]
[[Category: Chen, Z]]
[[Category: Guo, L.]]
[[Category: Guo, L]]
[[Category: Sprang, S R.]]
[[Category: Sprang, S R]]
[[Category: Sternweis, P C.]]
[[Category: Sternweis, P C]]
[[Category: Dh]]
[[Category: Dh]]
[[Category: Ph]]
[[Category: Ph]]

Revision as of 18:13, 21 December 2014

Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF

3odw, resolution 3.20Å

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