1syn: Difference between revisions

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[[Image:1syn.jpg|left|200px]]<br /><applet load="1syn" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1syn.jpg|left|200px]]
caption="1syn, resolution 2.0&Aring;" />
 
'''E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH BW1843U89 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)'''<br />
{{Structure
|PDB= 1syn |SIZE=350|CAPTION= <scene name='initialview01'>1syn</scene>, resolution 2.0&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=UMP:2'-DEOXYURIDINE+5'-MONOPHOSPHATE'>UMP</scene> and <scene name='pdbligand=F89:S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID'>F89</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]
|GENE=
}}
 
'''E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH BW1843U89 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1SYN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=UMP:'>UMP</scene> and <scene name='pdbligand=F89:'>F89</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SYN OCA].  
1SYN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SYN OCA].  


==Reference==
==Reference==
The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition., Stout TJ, Stroud RM, Structure. 1996 Jan 15;4(1):67-77. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8805515 8805515]
The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition., Stout TJ, Stroud RM, Structure. 1996 Jan 15;4(1):67-77. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8805515 8805515]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transferase (methyltransferase)]]
[[Category: transferase (methyltransferase)]]


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