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{{STRUCTURE_3w59|  PDB=3w59  |  SCENE=  }}
==Crystal structure of Galectin-1 in the lactose-unbound state(P212121)==
===Crystal structure of Galectin-1 in the lactose-unbound state(P212121)===
<StructureSection load='3w59' size='340' side='right' caption='[[3w59]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3w59]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W59 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w58|3w58]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LGALS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w59 RCSB], [http://www.ebi.ac.uk/pdbsum/3w59 PDBsum]</span></td></tr>
</table>


==Function==
==See Also==
[[http://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref>
*[[Galectin|Galectin]]
 
__TOC__
==About this Structure==
</StructureSection>
[[3w59]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W59 OCA].
[[Category: Human]]
 
[[Category: Kunishima, N]]
==Reference==
[[Category: Saburi, H]]
<references group="xtra"/><references/>
[[Category: Tanaka, T]]
[[Category: Kunishima, N.]]
[[Category: Saburi, H.]]
[[Category: Tanaka, T.]]
[[Category: Galectin]]
[[Category: Galectin]]
[[Category: Lactose unbound state]]
[[Category: Lactose unbound state]]
[[Category: Lectin]]
[[Category: Lectin]]
[[Category: Sugar binding protein]]
[[Category: Sugar binding protein]]

Revision as of 18:21, 21 December 2014

Crystal structure of Galectin-1 in the lactose-unbound state(P212121)

3w59, resolution 2.10Å

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