4nqm: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand== | |||
<StructureSection load='4nqm' size='340' side='right' caption='[[4nqm]], [[Resolution|resolution]] 1.58Å' scene=''> | |||
== Structural highlights == | |||
==Disease== | <table><tr><td colspan='2'>[[4nqm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NQM FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=Y1Z:2-CHLORO-N-[5-(3-METHYL[1,2,4]TRIAZOLO[3,4-A]PHTHALAZIN-6-YL)-2-(MORPHOLIN-4-YL)PHENYL]BENZENESULFONAMIDE'>Y1Z</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nqn|4nqn]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nqm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nqm RCSB], [http://www.ebi.ac.uk/pdbsum/4nqm PDBsum]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
== Function == | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | [[Category: Human]] | ||
<references | [[Category: Arrowsmith, C H]] | ||
[[Category: Arrowsmith, C H | [[Category: Bountra, C]] | ||
[[Category: Bountra, C | [[Category: Delft, F von]] | ||
[[Category: Delft, F von | [[Category: Edwards, A M]] | ||
[[Category: Edwards, A M | [[Category: Fedorov, O]] | ||
[[Category: Fedorov, O | [[Category: Felletar, I]] | ||
[[Category: Felletar, I | [[Category: Filippakopoulos, P]] | ||
[[Category: Filippakopoulos, P | [[Category: Knapp, S]] | ||
[[Category: Knapp, S | [[Category: Martin, S]] | ||
[[Category: Martin, S | [[Category: Picaud, S]] | ||
[[Category: Picaud, S | [[Category: Structural genomic]] | ||
[[Category: | |||
[[Category: Bromodomain]] | [[Category: Bromodomain]] | ||
[[Category: Inhibition]] | [[Category: Inhibition]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Small molecule inhibitor]] | [[Category: Small molecule inhibitor]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription-inhibitor complex]] | [[Category: Transcription-inhibitor complex]] | ||
Revision as of 18:29, 21 December 2014
Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand
| ||||||||||||
