4l8t: Difference between revisions
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==Structure of the Cargo Binding Domain from Human Myosin Vc== | |||
<StructureSection load='4l8t' size='340' side='right' caption='[[4l8t]], [[Resolution|resolution]] 2.95Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4l8t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L8T FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4j5l|4j5l]], [[4j5m|4j5m]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MYO5C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l8t RCSB], [http://www.ebi.ac.uk/pdbsum/4l8t PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Myosin V (MyoV) motors have been implicated in the intracellular transport of diverse cargoes including vesicles, organelles, RNA-protein complexes and regulatory proteins. Here, we have solved the cargo-binding domain (CBD) structures of the three human MyoV paralogs (Va, Vb and Vc), revealing subtle structural changes that drive functional differentiation and a novel redox mechanism controlling the CBD dimerization process, which is unique for the MyoVc subclass. Moreover, the cargo- and motor-binding sites were structurally assigned indicating the conservation of residues involved in the recognition of adaptors for peroxisome transport and providing high-resolution insights into motor domain (MD) inhibition by CBD. These results contribute to understanding the structural requirements for cargo transport, auto-inhibition and regulatory mechanisms in myosin V motors. | |||
Structural insights into functional overlapping and differentiation among myosin V motors.,Nascimento AF, Trindade DM, Tonoli CC, de Giuseppe PO, Assis LH, Honorato RV, de Oliveira PS, Mahajan P, Burgess-Brown NA, von Delft F, Larson RE, Murakami MT J Biol Chem. 2013 Oct 4. PMID:24097982<ref>PMID:24097982</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== | ==See Also== | ||
*[[Myosin|Myosin]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Assis, L H.P | [[Category: Assis, L H.P]] | ||
[[Category: Berridge, G | [[Category: Berridge, G]] | ||
[[Category: Burgess-Brown, N | [[Category: Burgess-Brown, N]] | ||
[[Category: Delft, F von | [[Category: Delft, F von]] | ||
[[Category: Krojer, T | [[Category: Krojer, T]] | ||
[[Category: Mahajan, P | [[Category: Mahajan, P]] | ||
[[Category: Murakami, M T | [[Category: Murakami, M T]] | ||
[[Category: Nascimento, A F.Z | [[Category: Nascimento, A F.Z]] | ||
[[Category: Tonoli, C C.C | [[Category: Tonoli, C C.C]] | ||
[[Category: Trindade, D M | [[Category: Trindade, D M]] | ||
[[Category: C-terminal globular tail]] | [[Category: C-terminal globular tail]] | ||
[[Category: Intracellular traffic]] | [[Category: Intracellular traffic]] | ||
[[Category: Protein transport]] | [[Category: Protein transport]] | ||
[[Category: Vesicle]] | [[Category: Vesicle]] | ||
Revision as of 18:33, 21 December 2014
Structure of the Cargo Binding Domain from Human Myosin Vc
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