1t05: Difference between revisions

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[[Image:1t05.gif|left|200px]]<br /><applet load="1t05" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1t05.gif|left|200px]]
caption="1t05, resolution 3.0&Aring;" />
 
'''HIV-1 reverse transcriptase crosslinked to template-primer with tenofovir-diphosphate bound as the incoming nucleotide substrate'''<br />
{{Structure
|PDB= 1t05 |SIZE=350|CAPTION= <scene name='initialview01'>1t05</scene>, resolution 3.0&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TNV:[2-(6-AMINO-9H-PURIN-9-YL)-1-METHYLETHOXY]METHYL-TRIPHOSPHATE'>TNV</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]
|GENE= POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''HIV-1 reverse transcriptase crosslinked to template-primer with tenofovir-diphosphate bound as the incoming nucleotide substrate'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1T05 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=TNV:'>TNV</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T05 OCA].  
1T05 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T05 OCA].  


==Reference==
==Reference==
Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir., Tuske S, Sarafianos SG, Clark AD Jr, Ding J, Naeger LK, White KL, Miller MD, Gibbs CS, Boyer PL, Clark P, Wang G, Gaffney BL, Jones RA, Jerina DM, Hughes SH, Arnold E, Nat Struct Mol Biol. 2004 May;11(5):469-74. Epub 2004 Apr 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15107837 15107837]
Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir., Tuske S, Sarafianos SG, Clark AD Jr, Ding J, Naeger LK, White KL, Miller MD, Gibbs CS, Boyer PL, Clark P, Wang G, Gaffney BL, Jones RA, Jerina DM, Hughes SH, Arnold E, Nat Struct Mol Biol. 2004 May;11(5):469-74. Epub 2004 Apr 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15107837 15107837]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: tenofovir]]
[[Category: tenofovir]]


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