4iwb: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
{{STRUCTURE_4iwb| PDB=4iwb | SCENE= }}
==Novel Fold of FliC/FliS Fusion Protein==
===Novel Fold of FliC/FliS Fusion Protein===
<StructureSection load='4iwb' size='340' side='right' caption='[[4iwb]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
{{ABSTRACT_PUBMED_24311586}}
== Structural highlights ==
<table><tr><td colspan='2'>[[4iwb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquae Aquae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IWB FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ory|1ory]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aq_1998, flaA, fliC, fliS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 AQUAE])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iwb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iwb RCSB], [http://www.ebi.ac.uk/pdbsum/4iwb PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Domain fusion is a useful tool in protein design. Here, the structure of a fusion of the heterodimeric flagella-assembly proteins FliS and FliC is reported. Although the ability of the fusion protein to maintain the structure of the heterodimer may be apparent, threading-based structural predictions do not properly fuse the heterodimer. Additional examples of naturally occurring heterodimers that are homologous to full-length proteins were identified. These examples highlight that the designed protein was engineered by the same tools as used in the natural evolution of proteins and that heterodimeric structures contain a wealth of information, currently unused, that can improve structural predictions.


==Function==
Protein design by fusion: implications for protein structure prediction and evolution.,Skorupka K, Han SK, Nam HJ, Kim S, Faham S Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2451-60. doi:, 10.1107/S0907444913022701. Epub 2013 Nov 19. PMID:24311586<ref>PMID:24311586</ref>
[[http://www.uniprot.org/uniprot/FLAA_AQUAE FLAA_AQUAE]] Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[4iwb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IWB OCA].
</div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:024311586</ref><references group="xtra"/><references/>
__TOC__
[[Category: Faham, S.]]
</StructureSection>
[[Category: Aquae]]
[[Category: Faham, S]]
[[Category: Motor protein]]
[[Category: Motor protein]]
[[Category: Novel fold]]
[[Category: Novel fold]]
Retrieved from "https://proteopedia.org/4iwb"