1t40: Difference between revisions

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[[Image:1t40.jpg|left|200px]]<br /><applet load="1t40" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1t40.jpg|left|200px]]
caption="1t40, resolution 1.80&Aring;" />
 
'''Crystal structure of human aldose reductase complexed with NADP and IDD552 at ph 5'''<br />
{{Structure
|PDB= 1t40 |SIZE=350|CAPTION= <scene name='initialview01'>1t40</scene>, resolution 1.80&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene> and <scene name='pdbligand=ID5:[5-FLUORO-2-({[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]AMINO}CARBONYL)PHENOXY]ACETIC ACID'>ID5</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21]
|GENE=
}}
 
'''Crystal structure of human aldose reductase complexed with NADP and IDD552 at ph 5'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1T40 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAP:'>NAP</scene> and <scene name='pdbligand=ID5:'>ID5</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T40 OCA].  
1T40 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T40 OCA].  


==Reference==
==Reference==
The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48., Ruiz F, Hazemann I, Mitschler A, Joachimiak A, Schneider T, Karplus M, Podjarny A, Acta Crystallogr D Biol Crystallogr. 2004 Aug;60(Pt 8):1347-54. Epub 2004, Jul 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15272156 15272156]
The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48., Ruiz F, Hazemann I, Mitschler A, Joachimiak A, Schneider T, Karplus M, Podjarny A, Acta Crystallogr D Biol Crystallogr. 2004 Aug;60(Pt 8):1347-54. Epub 2004, Jul 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15272156 15272156]
[[Category: Aldehyde reductase]]
[[Category: Aldehyde reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: x-ray crystallography]]
[[Category: x-ray crystallography]]


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