1t47: Difference between revisions

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[[Image:1t47.gif|left|200px]]<br /><applet load="1t47" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1t47.gif|left|200px]]
caption="1t47, resolution 2.50&Aring;" />
 
'''Structure of fe2-HPPD bound to NTBC'''<br />
{{Structure
|PDB= 1t47 |SIZE=350|CAPTION= <scene name='initialview01'>1t47</scene>, resolution 2.50&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene> and <scene name='pdbligand=NTD:2-{HYDROXY[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]METHYLENE}CYCLOHEXANE-1,3-DIONE'>NTD</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/4-hydroxyphenylpyruvate_dioxygenase 4-hydroxyphenylpyruvate dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.27 1.13.11.27]
|GENE= HPD, SAV5149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33903 Streptomyces avermitilis])
}}
 
'''Structure of fe2-HPPD bound to NTBC'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1T47 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_avermitilis Streptomyces avermitilis] with <scene name='pdbligand=FE2:'>FE2</scene> and <scene name='pdbligand=NTD:'>NTD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/4-hydroxyphenylpyruvate_dioxygenase 4-hydroxyphenylpyruvate dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.27 1.13.11.27] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T47 OCA].  
1T47 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_avermitilis Streptomyces avermitilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T47 OCA].  


==Reference==
==Reference==
Structure of the ferrous form of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide, NTBC., Brownlee JM, Johnson-Winters K, Harrison DH, Moran GR, Biochemistry. 2004 Jun 1;43(21):6370-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15157070 15157070]
Structure of the ferrous form of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide, NTBC., Brownlee JM, Johnson-Winters K, Harrison DH, Moran GR, Biochemistry. 2004 Jun 1;43(21):6370-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15157070 15157070]
[[Category: 4-hydroxyphenylpyruvate dioxygenase]]
[[Category: 4-hydroxyphenylpyruvate dioxygenase]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: triketone inhibitor]]
[[Category: triketone inhibitor]]


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