1tgh: Difference between revisions
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[[Image:1tgh.gif|left|200px]] | [[Image:1tgh.gif|left|200px]] | ||
'''TATA BINDING PROTEIN (TBP)/DNA COMPLEX''' | {{Structure | ||
|PDB= 1tgh |SIZE=350|CAPTION= <scene name='initialview01'>1tgh</scene>, resolution 2.900Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= TBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''TATA BINDING PROTEIN (TBP)/DNA COMPLEX''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1TGH is a [ | 1TGH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1TGH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGH OCA]. | ||
==Reference== | ==Reference== | ||
How proteins recognize the TATA box., Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE, J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:[http:// | How proteins recognize the TATA box., Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE, J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8757291 8757291] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: transcription factor]] | [[Category: transcription factor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:18:03 2008'' | ||
Revision as of 12:18, 20 March 2008
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| 1tgh, resolution 2.900Å | |||||||||||||
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| Gene: | TBP (Homo sapiens) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
TATA BINDING PROTEIN (TBP)/DNA COMPLEX
Overview
The crystal structure of a complex of human TATA-binding protein with TATA-sequence DNA has been solved, complementing earlier TBP/DNA analyses from Saccharomyces cerevisiae and Arabidopsis thaliana. Special insight into TATA box specificity is provided by considering the TBP/DNA complex, not as a protein molecule with bound DNA, but as a DNA duplex with a particularly large minor groove ligand. This point of view provides explanations for: (1) why T.A base-pairs are required rather than C.G; (2) why an alternation of T and A bases is needed; (3) how TBP recognizes the upstream and downstream ends of the TATA box in order to bind properly; and (4) why the second half of the TATA box can be more variable than the first.
Disease
Known diseases associated with this structure: Huntington disease-like-4 OMIM:[600075], Parkinson disease OMIM:[600075], Spinocerebellar ataxia 17 OMIM:[600075]
About this Structure
1TGH is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1TGH with [TATA-Binding Protein]. Full crystallographic information is available from OCA.
Reference
How proteins recognize the TATA box., Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE, J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:8757291
Page seeded by OCA on Thu Mar 20 14:18:03 2008
