2m1g: Difference between revisions
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==Parallel human telomeric quadruplex containing 2'F-ANA substitutions== | |||
<StructureSection load='2m1g' size='340' side='right' caption='[[2m1g]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2m1g]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M1G FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GFL:2-AMINO-9-(2-DEOXY-2-FLUORO-5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1,9-DIHYDRO-6H-PURIN-6-ONE'>GFL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m1g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m1g RCSB], [http://www.ebi.ac.uk/pdbsum/2m1g PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Human telomeric DNA quadruplexes can adopt different conformations in solution. We have found that arabinose, 2'F-arabinose, and ribose substitutions stabilize the propeller parallel G-quadruplex form over competing conformers, allowing NMR structural determination of this particularly significant nucleic acid structure. 2'F-arabinose substitution provides the greatest stabilization as a result of electrostatic (F-CH---O4') and pseudo-hydrogen-bond (F---H8) stabilizing interactions. In contrast, 2'F-rG substitution provokes a dramatic destabilization of the quadruplex structure due to unfavorable electrostatic repulsion between the phosphate and the 2'-F. | |||
Dramatic effect of furanose c2' substitution on structure and stability: directing the folding of the human telomeric quadruplex with a single fluorine atom.,Martin-Pintado N, Yahyaee-Anzahaee M, Deleavey GF, Portella G, Orozco M, Damha MJ, Gonzalez C J Am Chem Soc. 2013 Apr 10;135(14):5344-7. doi: 10.1021/ja401954t. Epub 2013 Mar , 27. PMID:23521511<ref>PMID:23521511</ref> | |||
[[Category: Damha, M J | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
[[Category: Deleavey, G F | </div> | ||
[[Category: Gonzalez, C | == References == | ||
[[Category: Martin-Pintado, N | <references/> | ||
[[Category: Orozco, M | __TOC__ | ||
[[Category: Portella, G | </StructureSection> | ||
[[Category: Yahyaee-Anzahaee, M | [[Category: Damha, M J]] | ||
[[Category: Deleavey, G F]] | |||
[[Category: Gonzalez, C]] | |||
[[Category: Martin-Pintado, N]] | |||
[[Category: Orozco, M]] | |||
[[Category: Portella, G]] | |||
[[Category: Yahyaee-Anzahaee, M]] | |||
[[Category: Dna]] | [[Category: Dna]] | ||
[[Category: Fluoro-arabinose]] | [[Category: Fluoro-arabinose]] | ||
Revision as of 06:37, 22 December 2014
Parallel human telomeric quadruplex containing 2'F-ANA substitutions
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