1tsm: Difference between revisions

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[[Image:1tsm.gif|left|200px]]<br /><applet load="1tsm" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1tsm.gif|left|200px]]
caption="1tsm, resolution 3.0&Aring;" />
 
'''L. CASEI THYMIDYLATE SYNTHASE WITH SPECIES SPECIFIC INHIBITOR'''<br />
{{Structure
|PDB= 1tsm |SIZE=350|CAPTION= <scene name='initialview01'>1tsm</scene>, resolution 3.0&Aring;
|SITE= <scene name='pdbsite=CAT:Active+Site+CYS'>CAT</scene>
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> and <scene name='pdbligand=MR2:3-DIPHENOL-6-NITRO-3H-BENZO[DE]ISOCHROMEN-1-ONE'>MR2</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]
|GENE=
}}
 
'''L. CASEI THYMIDYLATE SYNTHASE WITH SPECIES SPECIFIC INHIBITOR'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1TSM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei] with <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=MR2:'>MR2</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Known structural/functional Site: <scene name='pdbsite=CAT:Active+Site+CYS'>CAT</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSM OCA].  
1TSM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSM OCA].  


==Reference==
==Reference==
Structure-based design of inhibitors specific for bacterial thymidylate synthase., Stout TJ, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Santi DV, Kuntz ID, Stroud RM, Shoichet BK, Costi MP, Biochemistry. 1999 Feb 2;38(5):1607-17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9931028 9931028]
Structure-based design of inhibitors specific for bacterial thymidylate synthase., Stout TJ, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Santi DV, Kuntz ID, Stroud RM, Shoichet BK, Costi MP, Biochemistry. 1999 Feb 2;38(5):1607-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9931028 9931028]
[[Category: Lactobacillus casei]]
[[Category: Lactobacillus casei]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: structure-based drug design]]
[[Category: structure-based drug design]]


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