1tsv: Difference between revisions

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[[Image:1tsv.jpg|left|200px]]~~<br /><applet load~~="1tsv~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1tsv.jpg|left|200px]]

~~caption="~~1tsv, resolution 2.9Å" />

'''THYMIDYLATE SYNTHASE R179A MUTANT'''~~<br />~~

{{Structure

|PDB= 1tsv |SIZE=350|CAPTION= <scene name='initialview01'>1tsv</scene>, resolution 2.9Å

|SITE=

|LIGAND= <scene name='pdbligand=UMP:2'-DEOXYURIDINE 5'-MONOPHOSPHATE'>UMP</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]

|GENE=

}}

'''THYMIDYLATE SYNTHASE R179A MUTANT'''

==Overview==

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==About this Structure==

1TSV is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei] ~~with <scene name='pdbligand=UMP:'>UMP</scene> as [http://en.wikipedia~~.~~org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSV OCA].

1TSV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSV OCA].

==Reference==

Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase., Finer-Moore JS, Fauman EB, Morse RJ, Santi DV, Stroud RM, Protein Eng. 1996 Jan;9(1):69-75. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~9053905 9053905]

Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase., Finer-Moore JS, Fauman EB, Morse RJ, Santi DV, Stroud RM, Protein Eng. 1996 Jan;9(1):69-75. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9053905 9053905]

[[Category: Lactobacillus casei]]

[[Category: Single protein]]

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[[Category: transferase]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:22:40 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1tsv.jpg|left|200px]]<br /><applet load="1tsv" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1tsv.jpg|left|200px]]
-caption="1tsv, resolution 2.9&Aring;" />
-'''THYMIDYLATE SYNTHASE R179A MUTANT'''<br />
+ {{Structure
+|PDB= 1tsv |SIZE=350|CAPTION= <scene name='initialview01'>1tsv</scene>, resolution 2.9&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=UMP:2'-DEOXYURIDINE 5'-MONOPHOSPHATE'>UMP</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]
+|GENE=
+}}
+'''THYMIDYLATE SYNTHASE R179A MUTANT'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-TSV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei] with <scene name='pdbligand=UMP:'>UMP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSV OCA].
+TSV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSV OCA].
 ==Reference==
-Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase., Finer-Moore JS, Fauman EB, Morse RJ, Santi DV, Stroud RM, Protein Eng. 1996 Jan;9(1):69-75. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9053905 9053905]
+Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase., Finer-Moore JS, Fauman EB, Morse RJ, Santi DV, Stroud RM, Protein Eng. 1996 Jan;9(1):69-75. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9053905 9053905]
 [[Category: Lactobacillus casei]]
 [[Category: Single protein]]
@@ Line 21: / Line 30: @@
 [[Category: transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:17:00 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:22:40 2008''