1tys: Difference between revisions

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[[Image:1tys.gif|left|200px]]<br /><applet load="1tys" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1tys.gif|left|200px]]
caption="1tys, resolution 1.8&Aring;" />
 
'''WATER-MEDIATED SUBSTRATE(SLASH)PRODUCT DISCRIMINATION: THE PRODUCT COMPLEX OF THYMIDYLATE SYNTHASE AT 1.83 ANGSTROMS'''<br />
{{Structure
|PDB= 1tys |SIZE=350|CAPTION= <scene name='initialview01'>1tys</scene>, resolution 1.8&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=TMP:THYMIDINE-5'-PHOSPHATE'>TMP</scene> and <scene name='pdbligand=DHF:DIHYDROFOLIC ACID'>DHF</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]
|GENE=
}}
 
'''WATER-MEDIATED SUBSTRATE(SLASH)PRODUCT DISCRIMINATION: THE PRODUCT COMPLEX OF THYMIDYLATE SYNTHASE AT 1.83 ANGSTROMS'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1TYS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=TMP:'>TMP</scene> and <scene name='pdbligand=DHF:'>DHF</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TYS OCA].  
1TYS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TYS OCA].  


==Reference==
==Reference==
Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A., Fauman EB, Rutenber EE, Maley GF, Maley F, Stroud RM, Biochemistry. 1994 Feb 15;33(6):1502-11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8312270 8312270]
Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A., Fauman EB, Rutenber EE, Maley GF, Maley F, Stroud RM, Biochemistry. 1994 Feb 15;33(6):1502-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8312270 8312270]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transferase(methyltransferase)]]
[[Category: transferase(methyltransferase)]]


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