1u47: Difference between revisions

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[[Image:1u47.gif|left|200px]]<br /><applet load="1u47" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1u47.gif|left|200px]]
caption="1u47, resolution 2.00&Aring;" />
 
'''cytosine-8-Oxoguanine base pair at the polymerase active site'''<br />
{{Structure
|PDB= 1u47 |SIZE=350|CAPTION= <scene name='initialview01'>1u47</scene>, resolution 2.00&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SUC:SUCROSE'>SUC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7]
|GENE=
}}
 
'''cytosine-8-Oxoguanine base pair at the polymerase active site'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1U47 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus] with <scene name='pdbligand=SUC:'>SUC</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U47 OCA].  
1U47 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U47 OCA].  


==Reference==
==Reference==
Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase., Hsu GW, Ober M, Carell T, Beese LS, Nature. 2004 Sep 9;431(7005):217-21. Epub 2004 Aug 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15322558 15322558]
Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase., Hsu GW, Ober M, Carell T, Beese LS, Nature. 2004 Sep 9;431(7005):217-21. Epub 2004 Aug 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15322558 15322558]
[[Category: DNA-directed DNA polymerase]]
[[Category: DNA-directed DNA polymerase]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
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[[Category: dna polymerase i; dna replication; klenow fragment; protein-dna complex; 8oxoguanine; dna lesion; translation replication]]
[[Category: dna polymerase i; dna replication; klenow fragment; protein-dna complex; 8oxoguanine; dna lesion; translation replication]]


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