1upf: Difference between revisions

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[[Image:1upf.jpg|left|200px]]<br /><applet load="1upf" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1upf.jpg|left|200px]]
caption="1upf, resolution 2.3&Aring;" />
 
'''STRUCTURE OF THE URACIL PHOSPHORIBOSYLTRANSFERASE, MUTANT C128V BOUND TO THE DRUG 5-FLUOROURACIL'''<br />
{{Structure
|PDB= 1upf |SIZE=350|CAPTION= <scene name='initialview01'>1upf</scene>, resolution 2.3&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=URF:5-FLUOROURACIL'>URF</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Uracil_phosphoribosyltransferase Uracil phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.9 2.4.2.9]
|GENE=
}}
 
'''STRUCTURE OF THE URACIL PHOSPHORIBOSYLTRANSFERASE, MUTANT C128V BOUND TO THE DRUG 5-FLUOROURACIL'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1UPF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=URF:'>URF</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Uracil_phosphoribosyltransferase Uracil phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.9 2.4.2.9] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UPF OCA].  
1UPF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UPF OCA].  


==Reference==
==Reference==
Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding., Schumacher MA, Carter D, Scott DM, Roos DS, Ullman B, Brennan RG, EMBO J. 1998 Jun 15;17(12):3219-32. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9628859 9628859]
Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding., Schumacher MA, Carter D, Scott DM, Roos DS, Ullman B, Brennan RG, EMBO J. 1998 Jun 15;17(12):3219-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9628859 9628859]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Toxoplasma gondii]]
[[Category: Toxoplasma gondii]]
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[[Category: transferase]]
[[Category: transferase]]


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