1usn: Difference between revisions

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[[Image:1usn.jpg|left|200px]]<br /><applet load="1usn" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1usn.jpg|left|200px]]
caption="1usn, resolution 1.8&Aring;" />
 
'''CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THIADIAZOLE INHIBITOR PNU-142372'''<br />
{{Structure
|PDB= 1usn |SIZE=350|CAPTION= <scene name='initialview01'>1usn</scene>, resolution 1.8&Aring;
|SITE= <scene name='pdbsite=CA1:Ca1+Are+The+Ligands+Of+Ca+Ion+Ca+259'>CA1</scene>, <scene name='pdbsite=CA2:Ca2+Are+The+Ligands+Of+Ca+Ion+Ca+260'>CA2</scene>, <scene name='pdbsite=CA3:Ca3+Are+The+Ligands+Of+Ca+Ion+Ca+261'>CA3</scene>, <scene name='pdbsite=INH:Site+Inh+Is+The+Binding+Site+For+The+Urea-Thiadiazole+In+...'>INH</scene>, <scene name='pdbsite=ZN1:Zn1+Are+The+Ligands+Of+Catalytic+(Zn+257)+Zn+Ion'>ZN1</scene> and <scene name='pdbsite=ZN2:Zn2+Are+The+Ligands+Of+Structural+(Zn+258)+Zn+Ion'>ZN2</scene>
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=IN9:2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2YL)-UREIDO]-N-METHYL-3-PENTAFLUOROPHENYL-PROPIONAMIDE'>IN9</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17]
|GENE=
}}
 
'''CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THIADIAZOLE INHIBITOR PNU-142372'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1USN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=IN9:'>IN9</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] Known structural/functional Sites: <scene name='pdbsite=CA1:Ca1+Are+The+Ligands+Of+Ca+Ion+Ca+259'>CA1</scene>, <scene name='pdbsite=CA2:Ca2+Are+The+Ligands+Of+Ca+Ion+Ca+260'>CA2</scene>, <scene name='pdbsite=CA3:Ca3+Are+The+Ligands+Of+Ca+Ion+Ca+261'>CA3</scene>, <scene name='pdbsite=INH:Site+Inh+Is+The+Binding+Site+For+The+Urea-Thiadiazole+In+...'>INH</scene>, <scene name='pdbsite=ZN1:Zn1+Are+The+Ligands+Of+Catalytic+(Zn+257)+Zn+Ion'>ZN1</scene> and <scene name='pdbsite=ZN2:Zn2+Are+The+Ligands+Of+Structural+(Zn+258)+Zn+Ion'>ZN2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1USN OCA].  
1USN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1USN OCA].  


==Reference==
==Reference==
Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity., Finzel BC, Baldwin ET, Bryant GL Jr, Hess GF, Wilks JW, Trepod CM, Mott JE, Marshall VP, Petzold GL, Poorman RA, O'Sullivan TJ, Schostarez HJ, Mitchell MA, Protein Sci. 1998 Oct;7(10):2118-26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9792098 9792098]
Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity., Finzel BC, Baldwin ET, Bryant GL Jr, Hess GF, Wilks JW, Trepod CM, Mott JE, Marshall VP, Petzold GL, Poorman RA, O'Sullivan TJ, Schostarez HJ, Mitchell MA, Protein Sci. 1998 Oct;7(10):2118-26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9792098 9792098]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: metalloprotease]]
[[Category: metalloprotease]]


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