1utt: Difference between revisions

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[[Image:1utt.jpg|left|200px]]<br /><applet load="1utt" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1utt.jpg|left|200px]]
caption="1utt, resolution 2.2&Aring;" />
 
'''CRYSTAL STRUCTURE OF MMP-12 COMPLEXED TO 2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHYL-4-(4-ETHOXY[1,1-BIPHENYL]-4-YL)-4-OXOBUTANOIC ACID'''<br />
{{Structure
|PDB= 1utt |SIZE=350|CAPTION= <scene name='initialview01'>1utt</scene>, resolution 2.2&Aring;
|SITE= <scene name='pdbsite=ZN2:Ca+Binding+Site+For+Chain+A'>ZN2</scene>
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HAE:ACETOHYDROXAMIC+ACID'>HAE</scene> and <scene name='pdbligand=CP8:2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL) ETHYL-4-(4'-ETHOXY [1,1'-BIPHENYL]-4-YL)-4-OXOBUTANOIC ACID'>CP8</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65]
|GENE=
}}
 
'''CRYSTAL STRUCTURE OF MMP-12 COMPLEXED TO 2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHYL-4-(4-ETHOXY[1,1-BIPHENYL]-4-YL)-4-OXOBUTANOIC ACID'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1UTT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=HAE:'>HAE</scene> and <scene name='pdbligand=CP8:'>CP8</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] Known structural/functional Site: <scene name='pdbsite=ZN2:Ca+Binding+Site+For+Chain+A'>ZN2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UTT OCA].  
1UTT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UTT OCA].  


==Reference==
==Reference==
Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12., Morales R, Perrier S, Florent JM, Beltra J, Dufour S, De Mendez I, Manceau P, Tertre A, Moreau F, Compere D, Dublanchet AC, O'Gara M, J Mol Biol. 2004 Aug 20;341(4):1063-76. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15289103 15289103]
Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12., Morales R, Perrier S, Florent JM, Beltra J, Dufour S, De Mendez I, Manceau P, Tertre A, Moreau F, Compere D, Dublanchet AC, O'Gara M, J Mol Biol. 2004 Aug 20;341(4):1063-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15289103 15289103]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Macrophage elastase]]
[[Category: Macrophage elastase]]
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[[Category: non-zinc chelator]]
[[Category: non-zinc chelator]]


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