1uun: Difference between revisions
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[[Image:1uun.jpg|left|200px]] | [[Image:1uun.jpg|left|200px]] | ||
'''MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)''' | {{Structure | ||
|PDB= 1uun |SIZE=350|CAPTION= <scene name='initialview01'>1uun</scene>, resolution 2.5Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
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'''MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1UUN is a [ | 1UUN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUN OCA]. | ||
==Reference== | ==Reference== | ||
The structure of a mycobacterial outer-membrane channel., Faller M, Niederweis M, Schulz GE, Science. 2004 Feb 20;303(5661):1189-92. PMID:[http:// | The structure of a mycobacterial outer-membrane channel., Faller M, Niederweis M, Schulz GE, Science. 2004 Feb 20;303(5661):1189-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14976314 14976314] | ||
[[Category: Mycobacterium smegmatis]] | [[Category: Mycobacterium smegmatis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: porin]] | [[Category: porin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:36:59 2008'' | ||
Revision as of 12:37, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)
Overview
Mycobacteria have low-permeability outer membranes that render them resistant to most antibiotics. Hydrophilic nutrients can enter by way of transmembrane-channel proteins called porins. An x-ray analysis of the main porin from Mycobacterium smegmatis, MspA, revealed a homooctameric goblet-like conformation with a single central channel. This is the first structure of a mycobacterial outer-membrane protein. No structure-related protein was found in the Protein Data Bank. MspA contains two consecutive beta barrels with nonpolar outer surfaces that form a ribbon around the porin, which is too narrow to fit the thickness of the mycobacterial outer membrane in contemporary models.
About this Structure
1UUN is a Single protein structure of sequence from Mycobacterium smegmatis. Full crystallographic information is available from OCA.
Reference
The structure of a mycobacterial outer-membrane channel., Faller M, Niederweis M, Schulz GE, Science. 2004 Feb 20;303(5661):1189-92. PMID:14976314
Page seeded by OCA on Thu Mar 20 14:36:59 2008
