1uwb: Difference between revisions

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[[Image:1uwb.jpg|left|200px]]<br /><applet load="1uwb" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1uwb.jpg|left|200px]]
caption="1uwb, resolution 3.2&Aring;" />
 
'''TYR 181 CYS HIV-1 RT/8-CL TIBO'''<br />
{{Structure
|PDB= 1uwb |SIZE=350|CAPTION= <scene name='initialview01'>1uwb</scene>, resolution 3.2&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=TBO:5-CHLORO-8-METHYL-7-(3-METHYL-BUT-2-ENYL)-6,7,8,9-TETRAHYDRO-2H-2,7,9A-TRIAZA-BENZO[CD]AZULENE-1-THIONE'>TBO</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]
|GENE=
}}
 
'''TYR 181 CYS HIV-1 RT/8-CL TIBO'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1UWB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_12) Human immunodeficiency virus type 1 (isolate 12)] with <scene name='pdbligand=TBO:'>TBO</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWB OCA].  
1UWB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_12) Human immunodeficiency virus type 1 (isolate 12)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWB OCA].  


==Reference==
==Reference==
Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant., Das K, Ding J, Hsiou Y, Clark AD Jr, Moereels H, Koymans L, Andries K, Pauwels R, Janssen PA, Boyer PL, Clark P, Smith RH Jr, Kroeger Smith MB, Michejda CJ, Hughes SH, Arnold E, J Mol Biol. 1996 Dec 20;264(5):1085-100. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9000632 9000632]
Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant., Das K, Ding J, Hsiou Y, Clark AD Jr, Moereels H, Koymans L, Andries K, Pauwels R, Janssen PA, Boyer PL, Clark P, Smith RH Jr, Kroeger Smith MB, Michejda CJ, Hughes SH, Arnold E, J Mol Biol. 1996 Dec 20;264(5):1085-100. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9000632 9000632]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus type 1 (isolate 12)]]
[[Category: Human immunodeficiency virus type 1 (isolate 12)]]
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[[Category: Hsiou, Y.]]
[[Category: Hsiou, Y.]]
[[Category: TBO]]
[[Category: TBO]]
[[Category: aids]]
[[Category: aid]]
[[Category: aspartyl protease]]
[[Category: aspartyl protease]]
[[Category: drug-resistant mutant]]
[[Category: drug-resistant mutant]]
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[[Category: tyr181cys hiv-1 rt/8-cl tibo]]
[[Category: tyr181cys hiv-1 rt/8-cl tibo]]


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