1uxg: Difference between revisions

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[[Image:1uxg.gif|left|200px]]<br /><applet load="1uxg" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1uxg.gif|left|200px]]
caption="1uxg, resolution 1.90&Aring;" />
 
'''LARGE IMPROVEMENT IN THE THERMAL STABILITY OF A TETRAMERIC MALATE DEHYDROGENASE BY SINGLE POINT MUTATIONS AT THE DIMER-DIMER INTERFACE.'''<br />
{{Structure
|PDB= 1uxg |SIZE=350|CAPTION= <scene name='initialview01'>1uxg</scene>, resolution 1.90&Aring;
|SITE= <scene name='pdbsite=AC1:Fmr+Binding+Site+For+Chain+B'>AC1</scene>
|LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene> and <scene name='pdbligand=FMR:FUMARATE'>FMR</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Malate_dehydrogenase Malate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.37 1.1.1.37]
|GENE=
}}
 
'''LARGE IMPROVEMENT IN THE THERMAL STABILITY OF A TETRAMERIC MALATE DEHYDROGENASE BY SINGLE POINT MUTATIONS AT THE DIMER-DIMER INTERFACE.'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1UXG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Chloroflexus_aurantiacus Chloroflexus aurantiacus] with <scene name='pdbligand=NAD:'>NAD</scene> and <scene name='pdbligand=FMR:'>FMR</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Malate_dehydrogenase Malate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.37 1.1.1.37] Known structural/functional Site: <scene name='pdbsite=AC1:Fmr+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UXG OCA].  
1UXG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Chloroflexus_aurantiacus Chloroflexus aurantiacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UXG OCA].  


==Reference==
==Reference==
Large improvement in the thermal stability of a tetrameric malate dehydrogenase by single point mutations at the dimer-dimer interface., Bjork A, Dalhus B, Mantzilas D, Sirevag R, Eijsink VG, J Mol Biol. 2004 Aug 27;341(5):1215-26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15321717 15321717]
Large improvement in the thermal stability of a tetrameric malate dehydrogenase by single point mutations at the dimer-dimer interface., Bjork A, Dalhus B, Mantzilas D, Sirevag R, Eijsink VG, J Mol Biol. 2004 Aug 27;341(5):1215-26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15321717 15321717]
[[Category: Chloroflexus aurantiacus]]
[[Category: Chloroflexus aurantiacus]]
[[Category: Malate dehydrogenase]]
[[Category: Malate dehydrogenase]]
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[[Category: tricarboxylic acid cycle]]
[[Category: tricarboxylic acid cycle]]


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