2yuk: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2yuk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YUK FirstGlance]. <br> | <table><tr><td colspan='2'>[[2yuk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YUK FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MLL3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MLL3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yuk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yuk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yuk RCSB], [http://www.ebi.ac.uk/pdbsum/2yuk PDBsum], [http://www.topsan.org/Proteins/RSGI/2yuk TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yuk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yuk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yuk RCSB], [http://www.ebi.ac.uk/pdbsum/2yuk PDBsum], [http://www.topsan.org/Proteins/RSGI/2yuk TOPSAN]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/MLL3_HUMAN MLL3_HUMAN]] Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.<ref>PMID:17500065</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Histone-lysine N-methyltransferase]] | [[Category: Histone-lysine N-methyltransferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Abe, H | [[Category: Abe, H]] | ||
[[Category: Harada, T | [[Category: Harada, T]] | ||
[[Category: Kigawa, T | [[Category: Kigawa, T]] | ||
[[Category: Koshiba, S | [[Category: Koshiba, S]] | ||
[[Category: Miyamoto, K | [[Category: Miyamoto, K]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Tochio, N | [[Category: Tochio, N]] | ||
[[Category: Watanabe, S | [[Category: Watanabe, S]] | ||
[[Category: Yokoyama, S | [[Category: Yokoyama, S]] | ||
[[Category: H3 lysine-4 specific mll3]] | [[Category: H3 lysine-4 specific mll3]] | ||
[[Category: Histone-lysine n-methyltransferase]] | [[Category: Histone-lysine n-methyltransferase]] | ||
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[[Category: National project on protein structural and functional analyse]] | [[Category: National project on protein structural and functional analyse]] | ||
[[Category: Nppsfa]] | [[Category: Nppsfa]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 06:51, 24 December 2014
Solution structure of the HMG box of human Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Histone-lysine N-methyltransferase
- Homo sapiens
- Abe, H
- Harada, T
- Kigawa, T
- Koshiba, S
- Miyamoto, K
- Structural genomic
- Tochio, N
- Watanabe, S
- Yokoyama, S
- H3 lysine-4 specific mll3
- Histone-lysine n-methyltransferase
- Homologous to alr protein
- National project on protein structural and functional analyse
- Nppsfa
- Rsgi
- Transferase
