1w19: Difference between revisions

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[[Image:1w19.gif|left|200px]]<br /><applet load="1w19" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1w19.gif|left|200px]]
caption="1w19, resolution 2.00&Aring;" />
 
'''LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 3-(1,3,7-TRIHYDRO-9-D-RIBITYL-2,6,8-PURINETRIONE-7-YL) PROPANE 1-PHOSPHATE'''<br />
{{Structure
|PDB= 1w19 |SIZE=350|CAPTION= <scene name='initialview01'>1w19</scene>, resolution 2.00&Aring;
|SITE= <scene name='pdbsite=AC1:D1d+Binding+Site+For+Chain+E'>AC1</scene>
|LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=DTU:(2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTU</scene>, <scene name='pdbligand=T1P:3-{2,6,8-TRIOXO-9-[(2R,3S,4R)-2,3,4,5-TETRAHYDROXYPENTYL]-1,2,3,6,8,9-HEXAHYDRO-7H-PURIN-7-YL}PROPYL+DIHYDROGEN+PHOSPHATE'>T1P</scene>, <scene name='pdbligand=T2P:3-{2,6,8-TRIOXO-9-[(2S,3R,4R)-2,3,4,5-TETRAHYDROXYPENTYL]-1,2,3,6,8,9-HEXAHYDRO-7H-PURIN-7-YL}PROPYL+DIHYDROGEN+PHOSPHATE'>T2P</scene>, <scene name='pdbligand=DTV:(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTV</scene>, <scene name='pdbligand=T5P:3-{2,6,8-TRIOXO-9-[(2S,3S,4R)-2,3,4,5-TETRAHYDROXYPENTYL]-1,2,3,6,8,9-HEXAHYDRO-7H-PURIN-7-YL}PROPYL+DIHYDROGEN+PHOSPHATE'>T5P</scene>, <scene name='pdbligand=T4P:3-{2,6,8-TRIOXO-9-[(2R,3R,4R)-2,3,4,5-TETRAHYDROXYPENTYL]-1,2,3,6,8,9-HEXAHYDRO-7H-PURIN-7-YL}PROPYL+DIHYDROGEN+PHOSPHATE'>T4P</scene>, <scene name='pdbligand=D1D:(4S,5S)-1,2-DITHIANE-4,5-DIOL'>D1D</scene> and <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9]
|GENE=
}}
 
'''LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 3-(1,3,7-TRIHYDRO-9-D-RIBITYL-2,6,8-PURINETRIONE-7-YL) PROPANE 1-PHOSPHATE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1W19 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with <scene name='pdbligand=K:'>K</scene>, <scene name='pdbligand=DTU:'>DTU</scene>, <scene name='pdbligand=T1P:'>T1P</scene>, <scene name='pdbligand=T2P:'>T2P</scene>, <scene name='pdbligand=DTV:'>DTV</scene>, <scene name='pdbligand=T5P:'>T5P</scene>, <scene name='pdbligand=T4P:'>T4P</scene>, <scene name='pdbligand=D1D:'>D1D</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9] Known structural/functional Site: <scene name='pdbsite=AC1:D1d+Binding+Site+For+Chain+E'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W19 OCA].  
1W19 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W19 OCA].  


==Reference==
==Reference==
Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors., Morgunova E, Meining W, Illarionov B, Haase I, Jin G, Bacher A, Cushman M, Fischer M, Ladenstein R, Biochemistry. 2005 Mar 1;44(8):2746-58. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15723519 15723519]
Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors., Morgunova E, Meining W, Illarionov B, Haase I, Jin G, Bacher A, Cushman M, Fischer M, Ladenstein R, Biochemistry. 2005 Mar 1;44(8):2746-58. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15723519 15723519]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Riboflavin synthase]]
[[Category: Riboflavin synthase]]
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[[Category: x-ray diffraction]]
[[Category: x-ray diffraction]]


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