1w3v: Difference between revisions

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[[Image:1w3v.gif|left|200px]]<br /><applet load="1w3v" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1w3v.gif|left|200px]]
caption="1w3v, resolution 1.40&Aring;" />
 
'''ISOPENICILLIN N SYNTHASE D-(L-A-AMINOADIPOYL)-(3R)-METHYL-L-CYSTEINE D-A-HYDROXYISOVALERYL ESTER COMPLEX (ANAEROBIC)'''<br />
{{Structure
|PDB= 1w3v |SIZE=350|CAPTION= <scene name='initialview01'>1w3v</scene>, resolution 1.40&Aring;
|SITE= <scene name='pdbsite=AC1:Mdz+Binding+Site+For+Chain+A'>AC1</scene>
|LIGAND= <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene> and <scene name='pdbligand=MDZ:N~6~-METHYL-6-OXO-L-LYSINE - 2-[(3-MERCAPTOBUTANOYL)OXY]-3-METHYLBUTANOIC ACID'>MDZ</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Isopenicillin-N_synthase Isopenicillin-N synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.21.3.1 1.21.3.1]
|GENE=
}}
 
'''ISOPENICILLIN N SYNTHASE D-(L-A-AMINOADIPOYL)-(3R)-METHYL-L-CYSTEINE D-A-HYDROXYISOVALERYL ESTER COMPLEX (ANAEROBIC)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1W3V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Emericella_nidulans Emericella nidulans] with <scene name='pdbligand=FE2:'>FE2</scene> and <scene name='pdbligand=MDZ:'>MDZ</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Isopenicillin-N_synthase Isopenicillin-N synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.21.3.1 1.21.3.1] Known structural/functional Site: <scene name='pdbsite=AC1:Mdz+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3V OCA].  
1W3V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Emericella_nidulans Emericella nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3V OCA].  


==Reference==
==Reference==
Unexpected oxidation of a depsipeptide substrate analogue in crystalline isopenicillin N synthase., Daruzzaman A, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ, Chembiochem. 2006 Feb;7(2):351-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16444759 16444759]
Unexpected oxidation of a depsipeptide substrate analogue in crystalline isopenicillin N synthase., Daruzzaman A, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ, Chembiochem. 2006 Feb;7(2):351-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16444759 16444759]
[[Category: Emericella nidulans]]
[[Category: Emericella nidulans]]
[[Category: Isopenicillin-N synthase]]
[[Category: Isopenicillin-N synthase]]
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[[Category: penicillin biosynthesis]]
[[Category: penicillin biosynthesis]]


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