1w5q: Difference between revisions

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[[Image:1w5q.gif|left|200px]]<br /><applet load="1w5q" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1w5q.gif|left|200px]]
caption="1w5q, resolution 1.40&Aring;" />
 
'''STEPWISE INTRODUCTION OF ZINC BINDING SITE INTO PORPHOBILINOGEN SYNTHASE OF PSEUDOMONAS AERUGINOSA (MUTATIONS A129C, D131C, D139C, P132E, K229R)'''<br />
{{Structure
|PDB= 1w5q |SIZE=350|CAPTION= <scene name='initialview01'>1w5q</scene>, resolution 1.40&Aring;
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+B'>AC1</scene>
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> and <scene name='pdbligand=FMT:FORMIC ACID'>FMT</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24]
|GENE=
}}
 
'''STEPWISE INTRODUCTION OF ZINC BINDING SITE INTO PORPHOBILINOGEN SYNTHASE OF PSEUDOMONAS AERUGINOSA (MUTATIONS A129C, D131C, D139C, P132E, K229R)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1W5Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=FMT:'>FMT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] Known structural/functional Site: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5Q OCA].  
1W5Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5Q OCA].  


==Reference==
==Reference==
Tracking the evolution of porphobilinogen synthase metal dependence in vitro., Frere F, Reents H, Schubert WD, Heinz DW, Jahn D, J Mol Biol. 2005 Feb 4;345(5):1059-70. Epub 2004 Dec 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15644204 15644204]
Tracking the evolution of porphobilinogen synthase metal dependence in vitro., Frere F, Reents H, Schubert WD, Heinz DW, Jahn D, J Mol Biol. 2005 Feb 4;345(5):1059-70. Epub 2004 Dec 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15644204 15644204]
[[Category: Porphobilinogen synthase]]
[[Category: Porphobilinogen synthase]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: pseudomonas aeruginosa]]
[[Category: pseudomonas aeruginosa]]


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