1w78: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
Line 1: Line 1:
[[Image:1w78.gif|left|200px]]<br /><applet load="1w78" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1w78.gif|left|200px]]
caption="1w78, resolution 1.82&Aring;" />
 
'''E.COLI FOLC IN COMPLEX WITH DHPP AND ADP'''<br />
{{Structure
|PDB= 1w78 |SIZE=350|CAPTION= <scene name='initialview01'>1w78</scene>, resolution 1.82&Aring;
|SITE= <scene name='pdbsite=AC1:Adp+Binding+Site+For+Chain+A'>AC1</scene>
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=PD8:PHOSPHORYLATED+DIHYDROPTEROATE'>PD8</scene> and <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_synthase Dihydrofolate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.12 6.3.2.12]
|GENE=
}}
 
'''E.COLI FOLC IN COMPLEX WITH DHPP AND ADP'''
 


==Overview==
==Overview==
Line 7: Line 16:


==About this Structure==
==About this Structure==
1W78 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=PD8:'>PD8</scene> and <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_synthase Dihydrofolate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.12 6.3.2.12] Known structural/functional Site: <scene name='pdbsite=AC1:Adp+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W78 OCA].  
1W78 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W78 OCA].  


==Reference==
==Reference==
Escherichia coli FolC structure reveals an unexpected dihydrofolate binding site providing an attractive target for anti-microbial therapy., Mathieu M, Debousker G, Vincent S, Viviani F, Bamas-Jacques N, Mikol V, J Biol Chem. 2005 May 13;280(19):18916-22. Epub 2005 Feb 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15705579 15705579]
Escherichia coli FolC structure reveals an unexpected dihydrofolate binding site providing an attractive target for anti-microbial therapy., Mathieu M, Debousker G, Vincent S, Viviani F, Bamas-Jacques N, Mikol V, J Biol Chem. 2005 May 13;280(19):18916-22. Epub 2005 Feb 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15705579 15705579]
[[Category: Dihydrofolate synthase]]
[[Category: Dihydrofolate synthase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
Line 25: Line 34:
[[Category: SO4]]
[[Category: SO4]]
[[Category: atp-binding]]
[[Category: atp-binding]]
[[Category: dhfs]]
[[Category: dhf]]
[[Category: dihydrofolate synthase]]
[[Category: dihydrofolate synthase]]
[[Category: folate biosynthesis]]
[[Category: folate biosynthesis]]
Line 33: Line 42:
[[Category: synthase]]
[[Category: synthase]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:41:11 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:53:07 2008''
Retrieved from "https://proteopedia.org/1w78"