1wch: Difference between revisions

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[[Image:1wch.gif|left|200px]]<br /><applet load="1wch" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1wch.gif|left|200px]]
caption="1wch, resolution 1.85&Aring;" />
 
'''CRYSTAL STRUCTURE OF PTPL1 HUMAN TYROSINE PHOSPHATASE MUTATED IN COLORECTAL CANCER- EVIDENCE FOR A SECOND PHOSPHOTYROSINE SUBSTRATE RECOGNITION POCKET'''<br />
{{Structure
|PDB= 1wch |SIZE=350|CAPTION= <scene name='initialview01'>1wch</scene>, resolution 1.85&Aring;
|SITE= <scene name='pdbsite=AC1:Po4+Binding+Site+For+Chain+A'>AC1</scene>
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]
|GENE=
}}
 
'''CRYSTAL STRUCTURE OF PTPL1 HUMAN TYROSINE PHOSPHATASE MUTATED IN COLORECTAL CANCER- EVIDENCE FOR A SECOND PHOSPHOTYROSINE SUBSTRATE RECOGNITION POCKET'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1WCH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Known structural/functional Site: <scene name='pdbsite=AC1:Po4+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCH OCA].  
1WCH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCH OCA].  


==Reference==
==Reference==
Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket., Villa F, Deak M, Bloomberg GB, Alessi DR, van Aalten DM, J Biol Chem. 2005 Mar 4;280(9):8180-7. Epub 2004 Dec 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15611135 15611135]
Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket., Villa F, Deak M, Bloomberg GB, Alessi DR, van Aalten DM, J Biol Chem. 2005 Mar 4;280(9):8180-7. Epub 2004 Dec 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15611135 15611135]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Protein-tyrosine-phosphatase]]
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[[Category: tyrosine phosphatase]]
[[Category: tyrosine phosphatase]]


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