1we4: Difference between revisions

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[[Image:1we4.gif|left|200px]]<br /><applet load="1we4" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1we4.gif|left|200px]]
caption="1we4, resolution 1.70&Aring;" />
 
'''Crystal Structure of Class A beta-Lactamase Toho-1 G238C mutant'''<br />
{{Structure
|PDB= 1we4 |SIZE=350|CAPTION= <scene name='initialview01'>1we4</scene>, resolution 1.70&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]
|GENE=
}}
 
'''Crystal Structure of Class A beta-Lactamase Toho-1 G238C mutant'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1WE4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WE4 OCA].  
1WE4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WE4 OCA].  


==Reference==
==Reference==
An engineered disulfide bond between residues 69 and 238 in extended-spectrum beta-lactamase Toho-1 reduces its activity toward third-generation cephalosporins., Shimizu-Ibuka A, Matsuzawa H, Sakai H, Biochemistry. 2004 Dec 21;43(50):15737-45. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15595829 15595829]
An engineered disulfide bond between residues 69 and 238 in extended-spectrum beta-lactamase Toho-1 reduces its activity toward third-generation cephalosporins., Shimizu-Ibuka A, Matsuzawa H, Sakai H, Biochemistry. 2004 Dec 21;43(50):15737-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15595829 15595829]
[[Category: Beta-lactamase]]
[[Category: Beta-lactamase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: hydrolase]]
[[Category: hydrolase]]


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