4ny6: Difference between revisions
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''' | ==Neutron structure of leucine and valine methyl protonated type III antifreeze== | ||
<StructureSection load='4ny6' size='340' side='right' caption='[[4ny6]], [[Resolution|resolution]] 1.85Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ny6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NY6 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qf6|3qf6]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ny6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ny6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ny6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ny6 PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ANP12_ZOAAM ANP12_ZOAAM]] Contributes to protect fish blood from freezing at subzero sea water temperatures. Lowers the blood freezing point. Binds to nascent ice crystals and prevents further growth. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The 1.8 A resolution neutron structure of deuterated type III antifreeze protein in which the methyl groups of leucine and valine residues are selectively protonated is presented. Comparison between this and the 1.85 A resolution neutron structure of perdeuterated type III antifreeze protein indicates that perdeuteration improves the visibility of solvent molecules located in close vicinity to hydrophobic residues, as cancellation effects between H atoms of the methyl groups and nearby heavy-water molecules (D2O) are avoided. | |||
Perdeuteration: improved visualization of solvent structure in neutron macromolecular crystallography.,Fisher SJ, Blakeley MP, Howard EI, Petit-Haertlein I, Haertlein M, Mitschler A, Cousido-Siah A, Salvay AG, Popov A, Muller-Dieckmann C, Petrova T, Podjarny A Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3266-72. doi:, 10.1107/S1399004714021610. Epub 2014 Nov 28. PMID:25478844<ref>PMID:25478844</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Blakeley, M P]] | |||
[[Category: Cousido-Siah, A]] | |||
[[Category: Fisher, S J]] | |||
[[Category: Haertlein, M]] | |||
[[Category: Howard, E I]] | |||
[[Category: Mitschler, A]] | |||
[[Category: Muller-Dieckmann, C]] | |||
[[Category: Petite-Haertlein, I]] | |||
[[Category: Petrova, T]] | |||
[[Category: Podjarny, A D]] | |||
[[Category: Popov, A]] | |||
[[Category: Salvaya, A G]] | |||
[[Category: Antifreeze protein]] | |||
Revision as of 10:59, 24 December 2014
Neutron structure of leucine and valine methyl protonated type III antifreeze
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