4ci4: Difference between revisions

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'''Unreleased structure'''
==Structural basis for GL479 a dual Peroxisome Proliferator-Activated Receptor alpha agonist==
 
<StructureSection load='4ci4' size='340' side='right' caption='[[4ci4]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
The entry 4ci4 is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4ci4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CI4 FirstGlance]. <br>
Authors: Santos, J.C., Bernardes, A., Polikarpov, I.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Y1N:2-METHYL-2-[4-[2-[4-[(E)-PHENYLDIAZENYL]PHENOXY]ETHYL]PHENOXY]PROPANOIC+ACID'>Y1N</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ci5|4ci5]]</td></tr>
Description: Structural basis for GL479 a dual Peroxisome Proliferator-Activated Receptor alpha agonist
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ci4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ci4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ci4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ci4 PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN]] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Histone acetyltransferase]]
[[Category: Bernardes, A]]
[[Category: Polikarpov, I]]
[[Category: Santos, J C]]
[[Category: Dual agonist]]
[[Category: Gl479]]
[[Category: Nuclear receptor]]
[[Category: Ppar]]
[[Category: Transferase]]

Revision as of 11:03, 24 December 2014

Structural basis for GL479 a dual Peroxisome Proliferator-Activated Receptor alpha agonist

4ci4, resolution 2.30Å

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