4reb: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Structural Insights into 5' Flap DNA Unwinding and Incision by the Human FAN1 Dimer==

~~The entry~~ 4reb is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4reb]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4REB OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4REB FirstGlance].

~~Authors~~: ~~Zhao~~, Q., ~~Xue~~, X., Longerich, S., Sung, P., Xiong, Y.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4rea|4rea]], [[4rec|4rec]]</td></tr>

~~Description~~: ~~Structural Insights into 5' Flap DNA Unwinding and Incision by the Human FAN1 Dimer~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4reb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4reb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4reb RCSB], [http://www.ebi.ac.uk/pdbsum/4reb PDBsum]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN]] Karyomegalic interstitial nephritis. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[http://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN]] Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.<ref>PMID:20603015</ref> <ref>PMID:20603016</ref> <ref>PMID:20603073</ref> <ref>PMID:20671156</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Longerich, S]]

[[Category: Sung, P]]

[[Category: Xiong, Y]]

[[Category: Xue, X]]

[[Category: Zhao, Q]]

[[Category: Fancid2]]

[[Category: Hjc]]

[[Category: Hydrolase-dna complex]]

[[Category: Nucleus]]

[[Category: Sap]]

[[Category: Structure specific nuclease]]

[[Category: Tpr]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Structural Insights into 5' Flap DNA Unwinding and Incision by the Human FAN1 Dimer==
+<StructureSection load='4reb' size='340' side='right' caption='[[4reb]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
-The entry 4reb is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4reb]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4REB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4REB FirstGlance]. <br>
-Authors: Zhao, Q., Xue, X., Longerich, S., Sung, P., Xiong, Y.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rea|4rea]], [[4rec|4rec]]</td></tr>
-Description: Structural Insights into 5' Flap DNA Unwinding and Incision by the Human FAN1 Dimer
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4reb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4reb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4reb RCSB], [http://www.ebi.ac.uk/pdbsum/4reb PDBsum]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN]] Karyomegalic interstitial nephritis. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN]] Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.<ref>PMID:20603015</ref> <ref>PMID:20603016</ref> <ref>PMID:20603073</ref> <ref>PMID:20671156</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Longerich, S]]
+[[Category: Sung, P]]
+[[Category: Xiong, Y]]
+[[Category: Xue, X]]
+[[Category: Zhao, Q]]
+[[Category: Fancid2]]
+[[Category: Hjc]]
+[[Category: Hydrolase-dna complex]]
+[[Category: Nucleus]]
+[[Category: Sap]]
+[[Category: Structure specific nuclease]]
+[[Category: Tpr]]