2jxx: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jxx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXX FirstGlance]. <br> | <table><tr><td colspan='2'>[[2jxx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXX FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NFATC2IP, NIP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NFATC2IP, NIP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxx RCSB], [http://www.ebi.ac.uk/pdbsum/2jxx PDBsum], [http://www.topsan.org/Proteins/NESGC/2jxx TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxx RCSB], [http://www.ebi.ac.uk/pdbsum/2jxx PDBsum], [http://www.topsan.org/Proteins/NESGC/2jxx TOPSAN]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/NF2IP_HUMAN NF2IP_HUMAN]] In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Butler, C | [[Category: Butler, C]] | ||
[[Category: Dhe-Paganon, S | [[Category: Dhe-Paganon, S]] | ||
[[Category: Doherty, R S | [[Category: Doherty, R S]] | ||
[[Category: Edwards, A M | [[Category: Edwards, A M]] | ||
[[Category: Fares, C | [[Category: Fares, C]] | ||
[[Category: Karra, M | [[Category: Karra, M]] | ||
[[Category: Lemak, A | [[Category: Lemak, A]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Srisailam, S]] | |||
[[Category: Srisailam, S | [[Category: Weigelt, J]] | ||
[[Category: Weigelt, J | [[Category: Yee, A]] | ||
[[Category: Yee, A | |||
[[Category: Cytoplasmic 2-interacting protein]] | [[Category: Cytoplasmic 2-interacting protein]] | ||
[[Category: Methylation]] | [[Category: Methylation]] | ||
[[Category: Nesg]] | [[Category: Nesg]] | ||
[[Category: Nfat complex]] | [[Category: Nfat complex]] | ||
[[Category: Nuclear factor of activated t-cell]] | [[Category: Nuclear factor of activated t-cell]] | ||
[[Category: Nucleus]] | [[Category: Nucleus]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: Protein structure initiative | [[Category: PSI, Protein structure initiative]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Ubiquitin like homologue]] | [[Category: Ubiquitin like homologue]] | ||
