1omy: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1omy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OMY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OMY FirstGlance]. <br> | <table><tr><td colspan='2'>[[1omy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OMY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OMY FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1omy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1omy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1omy RCSB], [http://www.ebi.ac.uk/pdbsum/1omy PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1omy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1omy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1omy RCSB], [http://www.ebi.ac.uk/pdbsum/1omy PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/SC12_MESMA SC12_MESMA]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission (By similarity). Shows a high toxicity toward insects and moderate toxicity against mammals.<ref>PMID:12925796</ref> <ref>PMID:17877370</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mesobuthus martensii]] | [[Category: Mesobuthus martensii]] | ||
[[Category: Chen, H | [[Category: Chen, H]] | ||
[[Category: Huang, Q | [[Category: Huang, Q]] | ||
[[Category: Huang, Y | [[Category: Huang, Y]] | ||
[[Category: Kusunoki, M | [[Category: Kusunoki, M]] | ||
[[Category: Miyake, H | [[Category: Miyake, H]] | ||
[[Category: Tang, Y | [[Category: Tang, Y]] | ||
[[Category: Alpha-insect toxin]] | [[Category: Alpha-insect toxin]] | ||
[[Category: Sodium channel]] | [[Category: Sodium channel]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
Revision as of 14:10, 24 December 2014
Crystal Structure of a Recombinant alpha-insect Toxin BmKaIT1 from the scorpion Buthus martensii Karsch
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