1xdd: Difference between revisions

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[[Image:1xdd.gif|left|200px]]~~<br /><applet load~~="1xdd~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1xdd.gif|left|200px]]

~~caption="~~1xdd, resolution 2.20Å" />

'''X-ray structure of LFA-1 I-domain in complex with LFA703 at 2.2A resolution'''~~<br />~~

{{Structure

|PDB= 1xdd |SIZE=350|CAPTION= <scene name='initialview01'>1xdd</scene>, resolution 2.20Å

|SITE=

|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=AAY:8-[2-((2S)-4-HYDROXY-1-{[5-(HYDROXYMETHYL)-6-METHOXY-2-NAPHTHYL]METHYL}-6-OXOPIPERIDIN-2-YL)ETHYL]-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL 2-METHYLBUTANOATE'>AAY</scene>

|ACTIVITY=

|GENE=

}}

'''X-ray structure of LFA-1 I-domain in complex with LFA703 at 2.2A resolution'''

==Overview==

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==About this Structure==

1XDD is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=AAY:'>AAY</scene> as [http://en.wikipedia.org/wiki/ligands ligands~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDD OCA].

1XDD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDD OCA].

==Reference==

Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo., Weitz-Schmidt G, Welzenbach K, Dawson J, Kallen J, J Biol Chem. 2004 Nov 5;279(45):46764-71. Epub 2004 Aug 10. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~15304496 15304496]

Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo., Weitz-Schmidt G, Welzenbach K, Dawson J, Kallen J, J Biol Chem. 2004 Nov 5;279(45):46764-71. Epub 2004 Aug 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15304496 15304496]

[[Category: Homo sapiens]]

[[Category: Single protein]]

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[[Category: rossman fold]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:08:24 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1xdd.gif|left|200px]]<br /><applet load="1xdd" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1xdd.gif|left|200px]]
-caption="1xdd, resolution 2.20&Aring;" />
-'''X-ray structure of LFA-1 I-domain in complex with LFA703 at 2.2A resolution'''<br />
+ {{Structure
+|PDB= 1xdd |SIZE=350|CAPTION= <scene name='initialview01'>1xdd</scene>, resolution 2.20&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=AAY:8-[2-((2S)-4-HYDROXY-1-{[5-(HYDROXYMETHYL)-6-METHOXY-2-NAPHTHYL]METHYL}-6-OXOPIPERIDIN-2-YL)ETHYL]-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL 2-METHYLBUTANOATE'>AAY</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''X-ray structure of LFA-1 I-domain in complex with LFA703 at 2.2A resolution'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-XDD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=AAY:'>AAY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDD OCA].
+XDD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDD OCA].
 ==Reference==
-Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo., Weitz-Schmidt G, Welzenbach K, Dawson J, Kallen J, J Biol Chem. 2004 Nov 5;279(45):46764-71. Epub 2004 Aug 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15304496 15304496]
+Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo., Weitz-Schmidt G, Welzenbach K, Dawson J, Kallen J, J Biol Chem. 2004 Nov 5;279(45):46764-71. Epub 2004 Aug 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15304496 15304496]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 22: / Line 31: @@
 [[Category: rossman fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:53:35 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:08:24 2008''