1xgi: Difference between revisions

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[[Image:1xgi.gif|left|200px]]<br /><applet load="1xgi" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1xgi.gif|left|200px]]
caption="1xgi, resolution 1.96&Aring;" />
 
'''AmpC beta-lactamase in complex with 3-(3-nitro-phenylsulfamoyl)-thiophene-2-carboxylic acid'''<br />
{{Structure
|PDB= 1xgi |SIZE=350|CAPTION= <scene name='initialview01'>1xgi</scene>, resolution 1.96&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NST:3-{[(3-NITROANILINE]SULFONYL}THIOPHENE-2-CARBOXYLIC ACID'>NST</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]
|GENE= ampC, ampA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''AmpC beta-lactamase in complex with 3-(3-nitro-phenylsulfamoyl)-thiophene-2-carboxylic acid'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1XGI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=NST:'>NST</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XGI OCA].  
1XGI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XGI OCA].  


==Reference==
==Reference==
Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture., Tondi D, Morandi F, Bonnet R, Costi MP, Shoichet BK, J Am Chem Soc. 2005 Apr 6;127(13):4632-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15796528 15796528]
Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture., Tondi D, Morandi F, Bonnet R, Costi MP, Shoichet BK, J Am Chem Soc. 2005 Apr 6;127(13):4632-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15796528 15796528]
[[Category: Beta-lactamase]]
[[Category: Beta-lactamase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: serine hydrolase]]
[[Category: serine hydrolase]]


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