1kd7: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1kd7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KD7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1kd7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KD7 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kd7 RCSB], [http://www.ebi.ac.uk/pdbsum/1kd7 PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kd7 RCSB], [http://www.ebi.ac.uk/pdbsum/1kd7 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/TN13B_HUMAN TN13B_HUMAN]] Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.<ref>PMID:10973284</ref> Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity).<ref>PMID:10973284</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Boriack-Sjodin, A | [[Category: Boriack-Sjodin, A]] | ||
[[Category: Cachero, T G | [[Category: Cachero, T G]] | ||
[[Category: Hsu, Y-M | [[Category: Hsu, Y-M]] | ||
[[Category: Kalled, S L | [[Category: Kalled, S L]] | ||
[[Category: Karpusas, M | [[Category: Karpusas, M]] | ||
[[Category: Mullen, C | [[Category: Mullen, C]] | ||
[[Category: Qian, F | [[Category: Qian, F]] | ||
[[Category: Strauch, K | [[Category: Strauch, K]] | ||
[[Category: Beta-sheet shandwich]] | [[Category: Beta-sheet shandwich]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
[[Category: Tnf]] | [[Category: Tnf]] | ||
