1xm9: Difference between revisions
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[[Image:1xm9.gif|left|200px]] | [[Image:1xm9.gif|left|200px]] | ||
'''Structure of the armadillo repeat domain of plakophilin 1''' | {{Structure | ||
|PDB= 1xm9 |SIZE=350|CAPTION= <scene name='initialview01'>1xm9</scene>, resolution 2.80Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= PKP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Structure of the armadillo repeat domain of plakophilin 1''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1XM9 is a [ | 1XM9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XM9 OCA]. | ||
==Reference== | ==Reference== | ||
Structure of the armadillo repeat domain of plakophilin 1., Choi HJ, Weis WI, J Mol Biol. 2005 Feb 11;346(1):367-76. Epub 2004 Dec 19. PMID:[http:// | Structure of the armadillo repeat domain of plakophilin 1., Choi HJ, Weis WI, J Mol Biol. 2005 Feb 11;346(1):367-76. Epub 2004 Dec 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15663951 15663951] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: armadillo repeat]] | [[Category: armadillo repeat]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:11:41 2008'' | ||
Revision as of 13:11, 20 March 2008
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| 1xm9, resolution 2.80Å | |||||||||||||
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| Gene: | PKP1 (Homo sapiens) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Structure of the armadillo repeat domain of plakophilin 1
Overview
The p120ctn subfamily of armadillo domain proteins has roles in modulating intercellular adhesion by cadherin-containing junctions. We have determined the crystal structure of the arm repeat domain from plakophilin-1 (PKP1), a member of the p120ctn subfamily that is found in desmosomes. The structure reveals that the domain has nine instead of the expected ten arm repeats. A sequence predicted to be an arm repeat is instead a large insert which serves as a wedge that produces a significant bend in the overall domain structure. Structure-based sequence alignments indicate that the nine repeats and large insert are common to this subfamily of armadillo proteins. A prominent basic patch on the surface of the protein may serve as a binding site for partners of these proteins.
Disease
Known disease associated with this structure: Ectodermal dysplasia/skin fragility syndrome OMIM:[601975]
About this Structure
1XM9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the armadillo repeat domain of plakophilin 1., Choi HJ, Weis WI, J Mol Biol. 2005 Feb 11;346(1):367-76. Epub 2004 Dec 19. PMID:15663951
Page seeded by OCA on Thu Mar 20 15:11:41 2008
