1xpk: Difference between revisions

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[[Image:1xpk.gif|left|200px]]<br /><applet load="1xpk" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1xpk.gif|left|200px]]
caption="1xpk, resolution 2.0&Aring;" />
 
'''CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS HMG-COA SYNTHASE WITH HMG-CoA AND WITH ACETOACETYL-COA AND ACETYLATED CYSTEINE'''<br />
{{Structure
|PDB= 1xpk |SIZE=350|CAPTION= <scene name='initialview01'>1xpk</scene>, resolution 2.0&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=HMG:3-HYDROXY-3-METHYLGLUTARYL-COENZYME+A'>HMG</scene> and <scene name='pdbligand=CAA:ACETOACETYL-COENZYME A'>CAA</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_synthase Hydroxymethylglutaryl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.10 2.3.3.10]
|GENE= mvaS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46170 Staphylococcus aureus subsp. aureus])
}}
 
'''CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS HMG-COA SYNTHASE WITH HMG-CoA AND WITH ACETOACETYL-COA AND ACETYLATED CYSTEINE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1XPK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=HMG:'>HMG</scene> and <scene name='pdbligand=CAA:'>CAA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_synthase Hydroxymethylglutaryl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.10 2.3.3.10] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPK OCA].  
1XPK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPK OCA].  


==Reference==
==Reference==
3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"., Theisen MJ, Misra I, Saadat D, Campobasso N, Miziorko HM, Harrison DH, Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16442-7. Epub 2004 Oct 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15498869 15498869]
3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"., Theisen MJ, Misra I, Saadat D, Campobasso N, Miziorko HM, Harrison DH, Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16442-7. Epub 2004 Oct 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15498869 15498869]
[[Category: Hydroxymethylglutaryl-CoA synthase]]
[[Category: Hydroxymethylglutaryl-CoA synthase]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: SO4]]
[[Category: SO4]]
[[Category: cholesterol biosynthesis]]
[[Category: cholesterol biosynthesis]]
[[Category: coenzyme a]]
[[Category: coenzyme some]]
[[Category: condensing enzyme]]
[[Category: condensing enzyme]]
[[Category: hmg-coa synthase]]
[[Category: hmg-coa synthase]]
[[Category: hmgs]]
[[Category: hmg]]
[[Category: thiolase fold]]
[[Category: thiolase fold]]


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