1xql: Difference between revisions

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[[Image:1xql.gif|left|200px]]<br /><applet load="1xql" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1xql.gif|left|200px]]
caption="1xql, resolution 1.80&Aring;" />
 
'''Effect of a Y265F Mutant on the Transamination Based Cycloserine Inactivation of Alanine Racemase'''<br />
{{Structure
|PDB= 1xql |SIZE=350|CAPTION= <scene name='initialview01'>1xql</scene>, resolution 1.80&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PMP:4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE'>PMP</scene>, <scene name='pdbligand=PMH:(5-HYDROXY-4-{[(3-HYDROXYISOXAZOL-4-YL)AMINO]METHYL}-6-METHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>PMH</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5'-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=4AX:(R)-4-AMINO-ISOXAZOLIDIN-3-ONE'>4AX</scene> and <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Alanine_racemase Alanine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.1 5.1.1.1]
|GENE= alr, dal ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Geobacillus stearothermophilus])
}}
 
'''Effect of a Y265F Mutant on the Transamination Based Cycloserine Inactivation of Alanine Racemase'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1XQL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus] with <scene name='pdbligand=PMP:'>PMP</scene>, <scene name='pdbligand=PMH:'>PMH</scene>, <scene name='pdbligand=PLP:'>PLP</scene>, <scene name='pdbligand=4AX:'>4AX</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Alanine_racemase Alanine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.1 5.1.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQL OCA].  
1XQL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQL OCA].  


==Reference==
==Reference==
Effect of a Y265F mutant on the transamination-based cycloserine inactivation of alanine racemase., Fenn TD, Holyoak T, Stamper GF, Ringe D, Biochemistry. 2005 Apr 12;44(14):5317-27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15807525 15807525]
Effect of a Y265F mutant on the transamination-based cycloserine inactivation of alanine racemase., Fenn TD, Holyoak T, Stamper GF, Ringe D, Biochemistry. 2005 Apr 12;44(14):5317-27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15807525 15807525]
[[Category: Alanine racemase]]
[[Category: Alanine racemase]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
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[[Category: tim barrel]]
[[Category: tim barrel]]


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