3gr4: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gr4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gr4 RCSB], [http://www.ebi.ac.uk/pdbsum/3gr4 PDBsum]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/KPYM_HUMAN KPYM_HUMAN]] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.<ref>PMID:17308100</ref> <ref>PMID:18191611</ref> <ref>PMID:21620138</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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==See Also==

*[[Pyruvate Kinase|Pyruvate Kinase]]

== References ==

__TOC__

</StructureSection>

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@@ Line 8: / Line 8: @@
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gr4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gr4 RCSB], [http://www.ebi.ac.uk/pdbsum/3gr4 PDBsum]</span></td></tr>
 </table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KPYM_HUMAN KPYM_HUMAN]] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.<ref>PMID:17308100</ref> <ref>PMID:18191611</ref> <ref>PMID:21620138</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 21: / Line 23: @@
 ==See Also==
 *[[Pyruvate Kinase|Pyruvate Kinase]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>