4keq: Difference between revisions
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==Crystal structure of 4-pyridoxolactonase, 5-pyridoxolactone bound== | |||
=== | <StructureSection load='4keq' size='340' side='right' caption='[[4keq]], [[Resolution|resolution]] 2.28Å' scene=''> | ||
== Structural highlights == | |||
==Function== | <table><tr><td colspan='2'>[[4keq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesorhizobium_loti Mesorhizobium loti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KEQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KEQ FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5PN:7-HYDROXY-6-METHYLFURO[3,4-C]PYRIDIN-3(1H)-ONE'>5PN</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kep|4kep]], [[3aj3|3aj3]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mlr6805 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=266835 Mesorhizobium loti])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-pyridoxolactonase 4-pyridoxolactonase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.27 3.1.1.27] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4keq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4keq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4keq RCSB], [http://www.ebi.ac.uk/pdbsum/4keq PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PDLA_RHILO PDLA_RHILO]] Involved in the degradation of pyridoxine or pyridoxamine (free, phosphate-unbound, forms of vitamin B6). Hydrolyzes 4-pyridoxolactone to 4-pyridoxic acid. Has lower activity toward N-hexanoyl-D,L-homoserine lactone, but is not active toward 5-pyridoxolactone and gamma-butyrolactone. | [[http://www.uniprot.org/uniprot/PDLA_RHILO PDLA_RHILO]] Involved in the degradation of pyridoxine or pyridoxamine (free, phosphate-unbound, forms of vitamin B6). Hydrolyzes 4-pyridoxolactone to 4-pyridoxic acid. Has lower activity toward N-hexanoyl-D,L-homoserine lactone, but is not active toward 5-pyridoxolactone and gamma-butyrolactone. | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: 4-pyridoxolactonase]] | [[Category: 4-pyridoxolactonase]] | ||
[[Category: Baba, S | [[Category: Mesorhizobium loti]] | ||
[[Category: Kobayashi, J | [[Category: Baba, S]] | ||
[[Category: Mikami, B | [[Category: Kobayashi, J]] | ||
[[Category: Mizutani, K | [[Category: Mikami, B]] | ||
[[Category: Takahashi, N | [[Category: Mizutani, K]] | ||
[[Category: Yagi, T | [[Category: Takahashi, N]] | ||
[[Category: Yoshikane, Y | [[Category: Yagi, T]] | ||
[[Category: Yoshikane, Y]] | |||
[[Category: Alpha-beta/beta-alpha fold]] | [[Category: Alpha-beta/beta-alpha fold]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Lactone]] | [[Category: Lactone]] | ||
Revision as of 16:17, 24 December 2014
Crystal structure of 4-pyridoxolactonase, 5-pyridoxolactone bound
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