2r25: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r25 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r25 RCSB], [http://www.ebi.ac.uk/pdbsum/2r25 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r25 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r25 RCSB], [http://www.ebi.ac.uk/pdbsum/2r25 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/YPD1_YEAST YPD1_YEAST]] Phosphorelay intermediate protein that is part of the branched SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment. Catalyzes the phosphoryl group transfer from the membrane-bound osmosensing histidine kinase SLN1 to two distinct response regulator proteins, SSK1 in the cytoplasm, and transcription factor SKN7 in the nucleus.<ref>PMID:11073911</ref> <ref>PMID:9843501</ref> [[http://www.uniprot.org/uniprot/SLN1_YEAST SLN1_YEAST]] Histidine kinase that acts as a osmosensor at the plasma membrane. Part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment. Under normal osmotic conditions, the histidine kinase autophosphorylates His-576. This phosphate is subsequently transferred to Asp-1144, from where it is relayed to 'His-64' of the phosphorelay intermediate protein YPD1. Under high osmolarity conditions, the histidine kinase is no longer active.<ref>PMID:8808622</ref> <ref>PMID:9843501</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Histidine kinase]] | [[Category: Histidine kinase]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Copeland, D M | [[Category: Copeland, D M]] | ||
[[Category: Soares, A S | [[Category: Soares, A S]] | ||
[[Category: West, A H | [[Category: West, A H]] | ||
[[Category: Zhao, X | [[Category: Zhao, X]] | ||
[[Category: Alpha5-beta5]] | [[Category: Alpha5-beta5]] | ||
[[Category: Four helix bundle]] | [[Category: Four helix bundle]] | ||
