2xhd: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xhd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XHD FirstGlance]. <br> | <table><tr><td colspan='2'>[[2xhd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XHD FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7T9:N-[(2S)-5-(6-FLUORO-3-PYRIDINYL)-2,3-DIHYDRO-1H-INDEN-2-YL]-2-PROPANESULFONAMIDE'>7T9</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7T9:N-[(2S)-5-(6-FLUORO-3-PYRIDINYL)-2,3-DIHYDRO-1H-INDEN-2-YL]-2-PROPANESULFONAMIDE'>7T9</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wjx|2wjx]], [[2wjw|2wjw]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wjx|2wjx]], [[2wjw|2wjw]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xhd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xhd RCSB], [http://www.ebi.ac.uk/pdbsum/2xhd PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xhd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xhd RCSB], [http://www.ebi.ac.uk/pdbsum/2xhd PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/GRIA2_HUMAN GRIA2_HUMAN]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:20614889</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Aldegheri, L | [[Category: Aldegheri, L]] | ||
[[Category: Andreotti, D | [[Category: Andreotti, D]] | ||
[[Category: Ballantine, S | [[Category: Ballantine, S]] | ||
[[Category: Bax, B D | [[Category: Bax, B D]] | ||
[[Category: Harker, A J | [[Category: Harker, A J]] | ||
[[Category: Harries, M | [[Category: Harries, M]] | ||
[[Category: Harris, A J | [[Category: Harris, A J]] | ||
[[Category: Lund, J | [[Category: Lund, J]] | ||
[[Category: Melarange, R | [[Category: Melarange, R]] | ||
[[Category: Mingardi, A | [[Category: Mingardi, A]] | ||
[[Category: Mookherjee, C | [[Category: Mookherjee, C]] | ||
[[Category: Mosley, J | [[Category: Mosley, J]] | ||
[[Category: Neve, M | [[Category: Neve, M]] | ||
[[Category: Oliosi, B | [[Category: Oliosi, B]] | ||
[[Category: Profeta, R | [[Category: Profeta, R]] | ||
[[Category: Smith, K J | [[Category: Smith, K J]] | ||
[[Category: Smith, P W | [[Category: Smith, P W]] | ||
[[Category: Spada, S | [[Category: Spada, S]] | ||
[[Category: Thewlis, K M | [[Category: Thewlis, K M]] | ||
[[Category: Ward, S E | [[Category: Ward, S E]] | ||
[[Category: Yusaf, S P | [[Category: Yusaf, S P]] | ||
[[Category: Ion channel]] | [[Category: Ion channel]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
